Epithelial-mesenchymal transition in pancreatic carcinoma.
Epithelial-mesenchymal transition in pancreatic carcinoma.
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DOI：
10.3390/cancers2042058
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发表时间：
2010-12-09
期刊：
影响因子：
5.2
通讯作者：
Beug H
中科院分区：
文献类型：
--
作者：
Maier HJ;Wirth T;Beug H
胰腺癌是癌症死亡的第四大原因，其特点是早期侵袭和转移。上皮间质转化（EMT）的发育程序对于肿瘤的快速进展具有潜在的重要性。在 EMT 过程中，肿瘤细胞失去其上皮特征并获得间充质细胞的特性，例如增强的运动性和侵袭性特征。本综述将讨论与胰腺癌 EMT 相关的最新发现。将概述胰腺癌 EMT 的证据和分子特征，以及 EMT 与相关主题（例如癌症干细胞和耐药性）的联系。
Pancreatic carcinoma is the fourth-leading cause of cancer death and is characterized by early invasion and metastasis. The developmental program of epithelial-mesenchymal transition (EMT) is of potential importance for this rapid tumor progression. During EMT, tumor cells lose their epithelial characteristics and gain properties of mesenchymal cells, such as enhanced motility and invasive features. This review will discuss recent findings pertinent to EMT in pancreatic carcinoma. Evidence for and molecular characteristics of EMT in pancreatic carcinoma will be outlined, as well as the connection of EMT to related topics, e.g., cancer stem cells and drug resistance.