Intracellular Control of β-Catenin and Intestinal Cell Fate by SIRT2.
Intracellular Control of β-Catenin and Intestinal Cell Fate by SIRT2.
复制标题
SIRT2 对β-连环蛋白和肠细胞命运的细胞内控制。
DOI：
10.1016/j.jcmgh.2020.02.003
复制
发表时间：
2020
影响因子：
7.2
通讯作者：
Frey,MarkR
中科院分区：
文献类型：
--
作者：
Frey,MarkR
Tight coordination of cell proliferation and differen-tiation is critical for the health of the intestinal epithelium, which accomplishes rapid and continuous turnover while maintaining a complex morphology and a regulated balance of stem, absorptive, and secretory cell populations. Disruption of this equilibrium can contribute to disorders such as inflammatory bowel disease (IBD) or colon cancer. At the same time, the epithelium needs to be able to dynamically alter its self-renewal and differentiation programs to protect against infection, injury, or chronic inflammation. Despite the importance of these processes, mechanisms that drive the context-dependent balance between proliferation and differentiation remain poorly understood.In a new study published in this issue of Cellular and Molecular Gastroenterology and Hepatology, Li et al 1 shed light on an important aspect of intestinal renewal—regional and positional Wnt signaling—by exploring the function of the sirtuin protein SIRT2. Li et al demonstrate that, unlike other sirtuins (especially SIRT1, which is expressed primarily in the lower crypt), SIRT2 is restricted to the postmitotic compartment in the intestinal and colonic epithelia of humans and mice, and is induced by differentiation signals. Using a Sirt2 knockout mouse, they show elongated intestines, greater villus height and crypt depth, and increased proliferation and stem cell markers in ileal crypts, accompanied by lineage-specific disruption in the balance of differentiated cells (more Paneth cells but fewer absorptive enterocytes and goblet cells).
