Effects of degradation and porosity on the load bearing properties of model hydroxyapatite bone scaffolds
Effects of degradation and porosity on the load bearing properties of model hydroxyapatite bone scaffolds
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DOI：
10.1002/jbm.a.30658
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发表时间：
2006-06-01
影响因子：
4.9
通讯作者：
Jamison, Russell D.
中科院分区：
文献类型：
--
作者：
Dellinger, Jennifer G.;Wojtowicz, Abigail M.;Jamison, Russell D.
研究了三种类型的模型羟基磷灰石 (HA) 支架在乙酸钠缓冲液 (pH 4) 中体外降解后的降解情况。使用压缩测试、扫描电子显微镜 (SEM)、电感耦合等离子体 (ICP) 分析和重量测量来评估降解情况。支架是采用基于胶体糊的机器人沉积的固体自由成型制造（SFF）技术制造的。支架具有类似于杆格的宏观结构。支架含有大孔（x-y方向270或680μm，z方向280μm）和微孔（1-30μm孔和孔<1μm）或仅大孔孔（x-y方向270μm，z方向280μm）。计算机辅助设计（CAD）程序控制大孔的尺寸和分布；微孔是通过聚甲基丙烯酸甲酯（PMMA）微球致孔剂（孔径1-30μm）和受控烧结（孔径<1μm）产生的。对于所有支架类型，支架的重量损失百分比以及溶液中的钙和磷离子浓度随着降解期的增加而增加。降解后，具有微孔的支架的压缩强度和压缩模量显着下降。对于没有微孔的支架，降解后强度和模量的变化没有统计学意义。没有微孔的支架的抗压强度明显大于有微孔的支架。 (c) 2006 年 Wiley 期刊公司
Degradation of three types of model hydroxyapatite (HA) scaffolds was studied after in vitro degradation in a sodium acetate buffer (pH 4). Degradation was evaluated using compression testing, scanning electron microscopy (SEM), inductively coupled plasma (ICP) analysis, and weight measurements. Scaffolds were fabricated with a solid freeform fabrication (SFF) technique based on the robotic deposition of colloidal pastes. Scaffolds had a macrostructure resembling a lattice of rods. Scaffolds contained either macropores (270 or 680 mu m in the x-y direction and 280 mu m in the z-direction) and micropores (1-30-mu m pores and pores < 1 mu m) or only macropores pores (270 mu m in the x-y direction and 280 mu m in the z-direction). A computer-aided design (CAD) program controlled the size and distribution of macropores; micropores were created by polymethylmethacrylate (PMMA) microsphere porogens (1-30-mu m pore diameter) and controlled sintering (pores < 1 mu m). Percent weight loss of the scaffolds and calcium and phosphorus ion concentrations in solution increased as the degradation period increased for all scaffold types. After degradation, compressive strength and compressive modulus decreased significantly for those scaffolds with microporosity. For scaffolds without microporosity, the changes in strength and modulus after degradation were not statistically significant. The compressive strength of scaffolds without microporosity was significantly greater than the scaffolds with microporosity. (c) 2006 Wiley Periodicals, Inc.