SRSF5 functions as a novel oncogenic splicing factor and is upregulated by oncogene SRSF3 in oral squamous cell carcinoma.
SRSF5 functions as a novel oncogenic splicing factor and is upregulated by oncogene SRSF3 in oral squamous cell carcinoma.
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SRSF5 作为一种新型致癌剪接因子，在口腔鳞状细胞癌中被致癌基因 SRSF3 上调。
DOI：
10.1016/j.bbamcr.2018.05.017
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Bian Z
中科院分区：
文献类型：
--
作者：
Yang S;Jia R;Bian Z
前体信使RNA的选择性剪接与肿瘤发生的关系越来越密切。富含丝氨酸/丝氨酸的蛋白（serine/casein-rich protein，SR）家族在前体mRNA选择性剪接的调控中起着关键作用。越来越多的证据表明SR蛋白家族参与肿瘤的发生。然而，SR蛋白在肿瘤发生中的功能和机制仍不清楚。在本研究中，我们发现丝氨酸/丝氨酸丰富的剪接因子5（SRSF 5）是一种新的致癌剪接因子，在口腔鳞状细胞癌（OSCC）组织和细胞中过表达，对OSCC细胞增殖和肿瘤形成至关重要。SRSF 5过表达可转化永生啮齿类动物成纤维细胞在裸鼠体内形成肿瘤，而SRSF 5在口腔鳞状细胞系中的下调可延缓细胞生长、细胞周期进展和肿瘤生长。SRSF 5的表达受自身调节机制控制。富含丝氨酸/丝氨酸的剪接因子3（SRSF 3）已被鉴定为癌基因。我们发现SRSF 5是SRSF 3的一个新靶点。SRSF 3损害SRSF 5的自动调节并促进癌细胞中SRSF 5的过表达。总之，本研究表明，SRSF 5是一种新的癌基因，在OSCC细胞中被SRSF 3上调。
Alternative splicing of precursor messenger RNA has been increasingly associated with tumorigenesis. The serine/arginine-rich protein (SR) family plays key roles in the regulation of pre-mRNA alternative splicing. Increasing evidence has demonstrated that the SR protein family is involved in tumorigenesis. However, the functions and mechanisms of SR proteins in tumourigenesis remain largely unknown. In the present study, we discovered that serine/arginine-rich splicing factor 5 (SRSF5) is a novel oncogenic splicing factor that is overexpressed in oral squamous cell carcinoma (OSCC) tissues and cells, being crucial for OSCC cell proliferation and tumor formation. Overexpression of SRSF5 transformed immortal rodent fibroblasts to form tumors in nude mice, while downregulation of SRSF5 in oral squamous cell lines retarded cell growth, cell cycle progression, and tumor growth. The expression of SRSF5 is controlled by an autoregulation mechanism. Serine/arginine-rich splicing factor 3 (SRSF3) has been identified as an oncogene. We found that SRSF5 is a novel target of SRSF3. SRSF3 impairs the autoregulation of SRSF5 and promotes SRSF5 overexpression in cancer cells. Altogether, the present study demonstrated that SRSF5 is a novel oncogene that is upregulated by SRSF3 in OSCC cells.
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影响因子：
9.2
作者：
Jia R;Li C;McCoy JP;Deng CX;Zheng ZM
通讯作者：
Zheng ZM
影响因子：
37.3
作者：
He X;Zhang P
通讯作者：
Zhang P
DOI：
10.1016/j.bbagrm.2013.11.006
发表时间：
2014-01
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Jang HN;Lee M;Loh TJ;Choi SW;Oh HK;Moon H;Cho S;Hong SE;Kim DH;Sheng Z;Green MR;Park D;Zheng X;Shen H
通讯作者：
Shen H
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影响因子：
4.6
作者：
Jia R;Zhang S;Liu M;Zhang Y;Liu Y;Fan M;Guo J
通讯作者：
Guo J
影响因子：
3.7
作者：
Gautrey HL;Tyson-Capper AJ
通讯作者：
Tyson-Capper AJ