Neuronal effects of nicotine during auditory selective attention in schizophrenia.
Neuronal effects of nicotine during auditory selective attention in schizophrenia.
复制标题
尼古丁在精神分裂症中选择性关注期间的神经元作用。
DOI：
10.1002/hbm.23040
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发表时间：
2016-01
影响因子：
4.8
通讯作者：
Tregellas JR
中科院分区：
文献类型：
--
作者：
Smucny J;Olincy A;Rojas DC;Tregellas JR
虽然尼古丁已被证明可以改善精神分裂症的注意力缺陷，但这种作用背后的神经生物学机制却知之甚少。我们假设尼古丁会调节精神分裂症患者腹侧顶叶皮层（VPC），海马和前扣带回中的注意力相关神经元反应的基础上，以前的研究结果在对照组。为了验证这一假设，本研究在一个队列的非吸烟患者和健康对照组使用听觉选择性注意任务与环境噪声干扰在安慰剂和尼古丁管理这些地区的反应。与我们的假设一致，在VPC和海马中观察到显著的诊断（对照组与患者）X药物（安慰剂与尼古丁）相互作用。这种相互作用是由安慰剂给药期间患者（相对于健康对照）的任务相关多动和尼古丁给药后患者（相对于安慰剂）的多动减少驱动的。在前扣带回中没有观察到显著的相互作用。VPC的任务相关性多动预测安慰剂治疗期间患者的任务表现较差。通过简明精神病评定量表测量，较差的任务表现也可预测患者的症状。这些结果首次表明尼古丁可能以选择性注意力依赖的方式调节精神分裂症患者的大脑活动。
Although nicotine has been shown to improve attention deficits in schizophrenia, the neurobiological mechanisms underlying this effect are poorly understood. We hypothesized that nicotine would modulate attention-associated neuronal response in schizophrenia patients in the ventral parietal cortex (VPC), hippocampus, and anterior cingulate based on previous findings in control subjects. To test this hypothesis, the present study examined response in these regions in a cohort of nonsmoking patients and healthy control subjects using an auditory selective attention task with environmental noise distractors during placebo and nicotine administration. In agreement with our hypothesis, significant diagnosis (Control vs. Patient) X drug (Placebo vs. Nicotine) interactions were observed in the VPC and hippocampus. The interaction was driven by task-associated hyperactivity in patients (relative to healthy controls) during placebo administration, and decreased hyperactivity in patients after nicotine administration (relative to placebo). No significant interaction was observed in the anterior cingulate. Task-associated hyperactivity of the VPC predicted poor task performance in patients during placebo. Poor task performance also predicted symptoms in patients as measured by the Brief Psychiatric Rating Scale. These results are the first to suggest that nicotine may modulate brain activity in a selective attention-dependent manner in schizophrenia.