Effects of oxymorphone and hydromorphone on the minimum alveolar concentration of isoflurane in dogs
Effects of oxymorphone and hydromorphone on the minimum alveolar concentration of isoflurane in dogs
复制标题
DOI：
10.1111/j.1467-2995.2005.00215.x
复制
发表时间：
2006-01-01
影响因子：
1.7
通讯作者：
Grant Maxie, M
中科院分区：
文献类型：
--
作者：
Machado, CE;Dyson, DH;Grant Maxie, M
目的 量化狗中与羟吗啡酮 (OXY) 或氢吗啡酮 (HYDRO) 相关的异氟烷 (ISO) 最低肺泡浓度 (MAC) 的变化。设计评估之间至少间隔 1 周的随机交叉研究。动物 六只年轻、健康、混种狗（1-3 岁），体重 24.7 +/- 4.70 kg。方法面罩诱导后，用 ISO 维持麻醉。使用机械通风 100% O-2。狗接受0.05 mg kg(-1) OXY、0.1 mg kg(-1) HYDRO 或1 mL 盐水（对照）静脉注射。在测试的每个 ISO 百分比下进行平衡（15 分钟）后，对趾蹼施加超最大电刺激并评估反应。在麻醉 4.5 小时内进行两次单独的 MAC 测定，并在给药后 1.5-2 和 4-4.5 小时完成评估。使用双因素方差分析来确定对 MAC 是否存在时间或治疗效果，并使用 Tukey 检验比较每个时间的药物效果。显着性报告为 p < 0.05。 结果 对照的平均 MAC 值 (+/- SD) 为 1.2 +/- 0.18 和 1.2 +/- 0.16%，OXY 为 0.7 +/- 0.15 和 1.0 +/- 0.15%，HYDRO 为 0.6 +/- 0.14 和 0.8 +/- 0.17%。 OXY 的初始 MAC 和 HYDRO 两次测定的 MAC 与对照 MAC 值显着不同。结论 OXY 和 HYDRO 均显着降低了 2 小时时狗的 ISO MAC。在大约 4.5 小时时，HYDRO 具有显着的 MAC 保留作用，而 OXY 则没有。 临床相关性 虽然 OXY 和 HYDRO 均在大约 2 小时时导致 ISO 的 MAC 显着降低，但 HYDRO 可能是长时间手术的首选，并且很少需要在 4.5 小时之前重复给药。
Objectives To quantify the change in the minimum alveolar concentration (MAC) of isoflurane (ISO) associated with oxymorphone (OXY) or hydromorphone (HYDRO) in dogs.Design Randomized crossover study with at least 1 week between assessments.Animals Six young, healthy, mixed-breed dogs (1-3 years old), weighing 24.7 +/- 4.70 kg.Methods Following mask induction, anesthesia was maintained with ISO in 100% O-2 using mechanical ventilation. The dogs received 0.05 mg kg(-1) OXY, 0.1 mg kg(-1) HYDRO, or 1 mL saline (control) IV. Following equilibration (15 minutes) at each percentage ISO tested, a supramaximal electrical stimulus was applied to the toe web and the response was assessed. Two separate MAC determinations were carried out during 4.5 hours of anesthesia, with completion of the evaluations at 1.5-2 and 4-4.5 hours after drug administration. A two-factor ANOVA was used to determine whether there was a time or treatment effect on MAC and a Tukey test compared the drug effects at each time. Significance is reported at p < 0.05.Results The mean MAC values (+/- SD) were 1.2 +/- 0.18 and 1.2 +/- 0.16% for control, 0.7 +/- 0.15 and 1.0 +/- 0.15% for OXY, and 0.6 +/- 0.14 and 0.8 +/- 0.17% for HYDRO. The initial MAC with OXY and the MAC determined at both times with HYDRO were significantly different from the control MAC values.Conclusions Both OXY and HYDRO significantly reduced the MAC of ISO in dogs at 2 hours. At approximately 4.5 hours, HYDRO had a significant MAC-sparing effect, whereas OXY did not.Clinical relevance Although both OXY and HYDRO resulted in a significant reduction in the MAC of ISO at approximately 2 hours, HYDRO may be preferred for procedures of long duration and rarely needs repeated dosing before 4.5 hours.