A facile strategy for fine-tuning the stability and drug release of stimuli-responsive cross-linked micellar nanoparticles towards precision drug delivery.
A facile strategy for fine-tuning the stability and drug release of stimuli-responsive cross-linked micellar nanoparticles towards precision drug delivery.
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刺激反应性交联的胶束纳米颗粒的稳定性和药物释放的轻松策略，以递送精确药物。
DOI：
10.1039/c7nr02530k
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发表时间：
2017-06-14
期刊：
影响因子：
6.7
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Xiao K;Lin TY;Lam KS;Li Y
精准给药对精准肿瘤学的应用有很大影响，可以更好地为患者提供护理。在这里，我们报告了一个简单的策略，微调的稳定性，药物释放和响应性的刺激响应交联纳米粒子对精确的药物输送。利用混合胶束法可以方便地制备一系列具有不同水平的胶束内二硫键交联的胶束纳米颗粒。这些胶束纳米颗粒的尺寸都在25-40 nm范围内，因此它们可以充分利用增强的渗透性和保留（EPR）效应用于肿瘤靶向药物递送。这些纳米粒子的性质，如临界胶束浓度（CMC），稳定性，药物释放和对还原环境的响应性可以很好地与交联（CMC）的水平相关。与由于急性毒性如溶血导致两种动物（小鼠和大鼠）死亡的具有0%交联度的胶束纳米颗粒相比，所有其他交联水平的纳米颗粒对于施用到动物中要安全得多。低交联度（20% & 50%）的胶束纳米粒对卵巢癌SKOV-3细胞的体外抗肿瘤效果明显优于100%交联的胶束纳米粒。一个简单的策略被描述为移动药物输送领域的一个重要步骤，向精确的药物输送。
Precision drug delivery has great impact on the application of precision oncology for better patient care. Here we report a facile strategy for fine-tuning the stability, drug release and responsiveness of stimuli-responsive cross-linked nanoparticles towards precision drug delivery. A series of micellar nanoparticles with different levels of intramicellar disulfide crosslinkages could be conveniently produced with a mixed micelle approach. These micellar nanoparticles were all within a size range of 25–40 nm so that they could take full advantage of the enhanced permeability and retention (EPR) effect for tumor-targeted drug delivery. The properties of these nanoparticles such as critical micelle concentration (CMC), stability, drug release and responsiveness to reductive environment could be well correlated to the levels of crosslink (LOC). Compared to the micellar nanoparticles with a LOC at 0% that caused death of animals of two species (mouse and rat) due to the acute toxicity such as hemolysis, the nanoparticles at all other levels of crosslink were much safer to be administered into animals. The in vitro antitumor efficacy of micellar nanoparticles crosslinked at lower levels (20% & 50%) were much more effective than that of 100% crosslinked micellar nanoparticles in SKOV-3 ovarian cancer cells. A facile strategy is described to move the field of drug delivery a major step forward towards precision drug delivery.
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影响因子：
29.4
作者：
Jiang, Xuan;Qu, Wei;Pan, Deng;Ren, Yong;Williford, John-Michael;Cui, Honggang;Luijten, Erik;Mao, Hai-Quan
通讯作者：
Mao, Hai-Quan
影响因子：
16.6
作者：
Li, Yuanpei;Xiao, Wenwu;Xiao, Kai;Berti, Lorenzo;Luo, Juntao;Tseng, Harry P.;Fung, Gabriel;Lam, Kit S.
通讯作者：
Lam, Kit S.
DOI：
10.1016/j.jconrel.2010.02.027
发表时间：
2010-06-15
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Li Y;Xiao K;Luo J;Lee J;Pan S;Lam KS
通讯作者：
Lam KS
影响因子：
11.2
作者：
Xiao K;Li Y;Lee JS;Gonik AM;Dong T;Fung G;Sanchez E;Xing L;Cheng HR;Luo J;Lam KS
通讯作者：
Lam KS
使用共同递送 siRNA 和地塞米松的聚合混合胶束靶向 NF-kB 信号传导用于关节炎治疗
影响因子：
14
作者：
Wang, Qin;Jiang, Hao;Sun, Xun
通讯作者：
Sun, Xun