Caspase Functions in Cell Death and Disease
Caspase Functions in Cell Death and Disease
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DOI：
10.1101/cshperspect.a008656
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发表时间：
2013-04-01
影响因子：
7.2
通讯作者：
Mak, Tak W.
中科院分区：
文献类型：
--
作者：
McIlwain, David R.;Berger, Thorsten;Mak, Tak W.
半胱天冬酶是一个内切蛋白酶家族，在控制炎症和细胞死亡的细胞调节网络中提供关键环节。这些酶的活化通过它们作为无活性酶原的产生而被严格控制，所述无活性酶原在促进它们聚集成二聚体或大分子复合物的信号传导事件之后获得催化活性。凋亡半胱天冬酶的活化导致底物的失活或活化，以及允许细胞组分的受控破坏的信号传导事件级联的产生。炎性半胱天冬酶的激活导致活性促炎细胞因子的产生和对各种内部和外部损伤的先天免疫应答的促进。半胱天冬酶的失调是人类疾病的基础，包括癌症和炎症性疾病，为这些疾病设计更好的治疗方法的主要努力是为了了解这些酶如何工作以及如何控制它们。
Caspases are a family of endoproteases that provide critical links in cell regulatory networks controlling inflammation and cell death. The activation of these enzymes is tightly controlled by their production as inactive zymogens that gain catalytic activity following signaling events promoting their aggregation into dimers or macromolecular complexes. Activation of apoptotic caspases results in inactivation or activation of substrates, and the generation of a cascade of signaling events permitting the controlled demolition of cellular components. Activation of inflammatory caspases results in the production of active proinflammatory cytokines and the promotion of innate immune responses to various internal and external insults. Dysregulation of caspases underlies human diseases including cancer and inflammatory disorders, and major efforts to design better therapies for these diseases seek to understand how these enzymes work and how they can be controlled.