Challenges and opportunities targeting mechanisms of epithelial injury and recovery in acute intestinal graft-versus-host disease.
Challenges and opportunities targeting mechanisms of epithelial injury and recovery in acute intestinal graft-versus-host disease.
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DOI：
10.1038/s41385-022-00527-6
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发表时间：
2022-04
影响因子：
8
通讯作者：
Lindemans, Caroline A.
中科院分区：
文献类型：
--
作者：
Jansen, Suze A.;Nieuwenhuis, Edward E. S.;Hanash, Alan M.;Lindemans, Caroline A.
尽管在免疫抑制预防和全面支持治疗方面取得了进展，但胃肠道(GI)移植物抗宿主病(GVHD)仍然是异基因造血干细胞移植(allo-HSCT)后的主要致命性副作用。越来越清楚的是，肠上皮除了是移植相关毒性和移植物抗宿主病的靶点外，在移植物抗宿主病的发病中也起着重要作用。在过去的二十年里，随着对肠上皮成分及其微环境的了解的加深，新的预防和治疗干预措施的发展，有可能保护肠上皮免受GVHD相关的损害，并促进其在损伤后的恢复。在这篇综述中，我们将讨论肠上皮损伤以及肠上皮在移植物抗宿主病发病机制中的作用。此外，我们将强调可能的方法，以保护胃肠道移植后的损害和刺激上皮再生，以促进肠道恢复。结合免疫调节、上皮保护和诱导再生的综合治疗方式可能是解锁粘膜恢复和优化急性肠移植物抗宿主病治疗的关键。
Despite advances in immunosuppressive prophylaxis and overall supportive care, gastrointestinal (GI) graft-versus-host disease (GVHD) remains a major, lethal side effect after allogeneic hematopoietic stem cell transplantation (allo-HSCT). It has become increasingly clear that the intestinal epithelium, in addition to being a target of transplant-related toxicity and GVHD, plays an important role in the onset of GVHD. Over the last two decades, increased understanding of the epithelial constituents and their microenvironment has led to the development of novel prophylactic and therapeutic interventions, with the potential to protect the intestinal epithelium from GVHD-associated damage and promote its recovery following insult. In this review, we will discuss intestinal epithelial injury and the role of the intestinal epithelium in GVHD pathogenesis. In addition, we will highlight possible approaches to protect the GI tract from damage posttransplant and to stimulate epithelial regeneration, in order to promote intestinal recovery. Combined treatment modalities integrating immunomodulation, epithelial protection, and induction of regeneration may hold the key to unlocking mucosal recovery and optimizing therapy for acute intestinal GVHD.
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影响因子：
29.4
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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作者：
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DOI：
10.4049/jimmunol.1601066
发表时间：
2017-09-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bradford EM;Ryu SH;Singh AP;Lee G;Goretsky T;Sinh P;Williams DB;Cloud AL;Gounaris E;Patel V;Lamping OF;Lynch EB;Moyer MP;De Plaen IG;Shealy DJ;Yang GY;Barrett TA
通讯作者：
Barrett TA