Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China
Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China
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DOI：
10.1007/s15010-020-01432-5
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发表时间：
2020-04-28
期刊：
影响因子：
7.5
通讯作者：
Zheng, Cheng
中科院分区：
文献类型：
--
作者：
Chen, Qingqing;Zheng, Zhencang;Zheng, Cheng
目的探讨台州市2019年冠状病毒病的临床特征。方法2020年1月1日至2020年3月11日在浙江省台州市公共卫生医学中心进行单中心回顾性研究。所有确诊为2019年冠状病毒病的患者都被纳入研究，他们的临床数据是通过审查电子病历收集的。比较重症患者和非重症患者的结局。结果在145名COVID-19住院患者中，平均年龄为47.5岁（标准差为14.6），54.5%为男性。高血压是最常见的合并症（15.2%），其次是糖尿病（9.7%）。常见症状为干咳（81.4%）、发热（75.2%）、纳差（42.8%）、乏力（40.7%）、胸闷（32.4%）、腹泻（26.9%）、头晕（20%）。根据影像学检查，79.3%的患者表现为双侧肺炎，18.6%表现为单侧肺炎，61.4%表现为磨玻璃样阴影，2.1%无异常结果。与非重症患者相比，重症患者年龄更大（平均年龄，52.8岁对45.3岁，p < 0.01），（16.3% vs. 6.9%，p = 0.08），体重指数较高（平均值，24.78 vs. 23.20，p = 0.02），并且更容易发热（90.7% vs. 68.6%，p = 0.01）、厌食（60.5% vs. 35.3%，p = 0.01）、胸闷（60.5% vs. 20.6%，p < 0.01）和呼吸困难（7.0% vs. 0%，p = 0.03）。43例重症患者中，6例（14%）接受高流量鼻导管氧疗，1例（2.3%）接受有创机械通气。结论老年患者或合并肥胖、糖尿病等疾病的患者病情较重。COVID-19的治疗仍处于实验阶段，需要更多的临床试验。
Objective The aim of this study was to investigate the clinical characteristics of Corona Virus Disease 2019 in Taizhou, China. Methods A single center retrospective observational study was performed between Jan 1, 2020 and Mar 11, 2020 at Taizhou Public Health Medical Center, Zhejiang, China. All patients with confirmed Corona Virus Disease 2019 were enrolled, and their clinical data were gathered by reviewing electronic medical records. Outcomes of severely ill patients and non-severely ill patients were compared. Results Of 145 hospitalized patients with COVID-19, the average age was 47.5 years old (standard deviation, 14.6) and 54.5% were men. Hypertension was the most common comorbidity (15.2%), followed by diabetes mellitus (9.7%). Common symptoms included dry cough (81.4%), fever (75.2%), anorexia (42.8%), fatigue (40.7%), chest tightness (32.4%), diarrhea (26.9%) and dizziness (20%). According to imaging examination, 79.3% patients showed bilateral pneumonia, 18.6% showed unilateral pneumonia, 61.4% showed ground-glass opacity, and 2.1% showed no abnormal result. Compared with non-severely ill patients, severely ill patients were older (mean, years, 52.8 vs. 45.3, p < 0.01), had a higher proportion of diabetes mellitus (16.3% vs. 6.9%, p = 0.08), had a higher body mass index (mean, 24.78 vs. 23.20, p = 0.02) and were more likely to have fever (90.7% vs. 68.6%, p = 0.01), anorexia (60.5% vs. 35.3%, p = 0.01), chest tightness (60.5% vs.20.6%, p < 0.01) and dyspnea (7.0% vs. 0%, p = 0.03). Of the 43 severely ill patients, 6 (14%) received high-flow nasal cannula oxygen therapy, and 1 (2.3%) received invasive mechanical ventilation. Conclusions Older patients or patients with comorbidities such as obesity or diabetes mellitus were more likely to have severe condition. Treatments of COVID-19 is still experimental and more clinical trials are needed.