Stretching Impacts Inflammation Resolution in Connective Tissue.
Stretching Impacts Inflammation Resolution in Connective Tissue.
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拉伸会影响结缔组织的炎症分辨率。
DOI：
10.1002/jcp.25263
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发表时间：
2016-07
影响因子：
5.6
通讯作者：
Langevin HM
中科院分区：
文献类型：
--
作者：
Berrueta L;Muskaj I;Olenich S;Butler T;Badger GJ;Colas RA;Spite M;Serhan CN;Langevin HM
急性炎症从一开始就伴随着专门的促溶解介质（SPMs）的释放，包括溶解蛋白，它们协调局部炎症的溶解。我们之前的研究表明，在卡拉胶引起的背部皮下炎症大鼠中，注射卡拉胶两周后，每天两次10分钟的拉伸可以减轻炎症并改善疼痛。在这项研究中，我们假设在炎症的急性期，结缔组织的拉伸激活了组织内的局部促溶解机制。在大鼠注射卡拉胶并随机分为拉伸组和非拉伸组48小时后，拉伸组减少了炎性病变的厚度和中性粒细胞计数，并增加了病变内的溶解蛋白（RvD1）浓度。此外，皮下注射溶解素可以模拟拉伸的效果。在离体实验中，结缔组织的拉伸减少了中性粒细胞的迁移，增加了组织RvD1浓度。这些结果证明了拉伸对结缔组织内炎症调节机制的直接机械影响。
Acute inflammation is accompanied from its outset by the release of specialized pro-resolving mediators (SPMs), including resolvins, that orchestrate the resolution of local inflammation. We showed earlier that, in rats with subcutaneous inflammation of the back induced by carrageenan, stretching for 10 minutes twice daily reduced inflammation and improved pain, two weeks after carrageenan injection. In this study, we hypothesized that stretching of connective tissue activates local pro-resolving mechanisms within the tissue in the acute phase of inflammation. In rats injected with carrageenan and randomized to stretch vs. no stretch for 48 hours, stretching reduced inflammatory lesion thickness and neutrophil count, and increased resolvin (RvD1) concentrations within lesions. Furthermore, subcutaneous resolvin injection mimicked the effect of stretching. In ex vivo experiments, stretching of connective tissue reduced the migration of neutrophils and increased tissue RvD1 concentration. These results demonstrate a direct mechanical impact of stretching on inflammation-regulation mechanisms within connective tissue.