Survival Study of Triple-Negative and Non-Triple-Negative Breast Cancer in a Brazilian Cohort
Survival Study of Triple-Negative and Non-Triple-Negative Breast Cancer in a Brazilian Cohort
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DOI：
10.1177/1179554918790563
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发表时间：
2018-07-27
影响因子：
2.2
通讯作者：
Bustamante Teixeira, Maria Teresa
中科院分区：
文献类型：
--
作者：
Goncalves, Homero, Jr.;Guerra, Maximiliano Ribeiro;Bustamante Teixeira, Maria Teresa
目的：分析巴西队列中三阴性乳腺癌 (TNBC) 和非 TNBC 的临床、病理和社会人口学方面，并确定潜在的预后因素。 方法：这项以医院为基础的回顾性队列研究纳入了 447 名在巴西东南部转诊中心接受治疗的乳腺癌女性。比较总生存率和无病生存率；结果：三阴性乳腺癌占乳腺癌诊断的 19.5%，并且在非白人和受教育程度较低的女性中更为普遍。 TNBC患者往往表现为III期癌症、p53高表达、淋巴细胞浸润和多灶性，并接受根治性手术和化疗。 TNBC 的 5 年总生存率和无病生存率分别为 62.1% 和 57.5%，非 TNBC 的 5 年总生存率和无病生存率分别为 80.8% 和 75.3%（P
OBJECTIVE: To analyze the clinical, pathological, and sociodemographic aspects between triple-negative breast cancer (TNBC) and non-TNBC in a Brazilian cohort and identify potential prognostic factors.METHODS: This hospital-based retrospective cohort study included 447 women with breast cancer treated at referral centers in Southeastern Brazil. Overall and disease-free survival were compared; prognostic factors were evaluated.RESULTS: Triple-negative breast cancer corresponded to 19.5% of breast cancer diagnosis and was more prevalent among nonwhite and less educated women. The patients with TNBC tended to present with stage III cancer, high p53 expression, lymphocytic infiltration, and multifocality and treated with radical surgery and chemotherapy. The 5-year overall and disease-free survival were 62.1% and 57.5% for TNBC and 80.8% and 75.3% for non-TNBC, respectively (P