Polymorphisms in complement system genes and risk of non-Hodgkin lymphoma.
Polymorphisms in complement system genes and risk of non-Hodgkin lymphoma.
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DOI：
10.1002/em.21675
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发表时间：
2012-03
影响因子：
2.8
通讯作者：
Lan, Qing
中科院分区：
文献类型：
--
作者：
Bassig, Bryan A.;Zheng, Tongzhang;Zhang, Yawei;Berndt, Sonja I.;Holford, Theodore R.;Hosgood, H. Dean, III;Hu, Wei;Leaderer, Brian;Yeager, Meredith;Menashe, Idan;Boyle, Peter;Xu, Jun;Zou, Kaiyong;Zhu, Yong;Chanock, Stephen;Rothman, Nathaniel;Lan, Qing
补体系统在炎症和免疫反应中起着重要作用，最近的证据表明它也可能在淋巴瘤发生中起作用。我们在康涅狄格州的妇女中进行了一项基于人群的病例对照研究，评估了补体系统基因的遗传变异与非霍奇金淋巴瘤（NHL）风险之间的关系。在432例高加索事件病例和494例频率匹配的对照中，对30个补体基因的标签SNP进行基因分型。一项基于基因的分析，调整了每个基因中基因分型的标签SNP的数量，显示C1 RL基因与NHL总体（P = 0.04）以及弥漫性大B细胞淋巴瘤（DLBCL）（P = 0.01）显著相关。基于SNP的分析表明，C1 RL rs3813729的C>T碱基替换（比值比（OR）CT = 0.60，95%置信区间（CI）= 0.42-0.87，Ptrend = 0.0062）与总体NHL和DLBCL风险降低相关（ORCT = 0.39，95% CI = 0.20-0.73; P趋势= 0.0034）。此外，两个补体基因中的SNP（C2 rs 497309，A>C和C3 rs344550，G>C）与边缘区淋巴瘤（MZL）正相关，C1 QG与CLL/SLL相关，但这些结果基于有限数量的病例。我们的研究结果表明补体系统在NHL易感性中的潜在作用;然而，我们的研究结果应被视为探索性的，需要进一步的重复来澄清这些初步发现。
The complement system plays an important role in inflammatory and immune responses, and recent evidence has suggested that it may also play a role in lymphomagenesis. We evaluated the association between genetic variation in complement system genes and risk of non-Hodgkin lymphoma (NHL) in a population-based case–control study conducted among women in Connecticut. Tag SNPs in 30 complement genes were genotyped in 432 Caucasian incident cases and 494 frequency-matched controls. A gene-based analysis that adjusted for the number of tag SNPs genotyped in each gene showed a significant association with NHL overall (P = 0.04) as well as with diffuse large B-cell lymphoma (DLBCL) (P = 0.01) for the C1RL gene. A SNP-based analysis showed that a C>T base substitution for C1RL rs3813729 (odds ratio (OR)CT = 0.60, 95% confidence interval (CI) = 0.42–0.87, Ptrend = 0.0062) was associated with a decreased risk of overall NHL, as well as for DLBCL (ORCT = 0.39, 95% CI = 0.20–0.73; Ptrend = 0.0034). Additionally, SNPs (C2 rs497309, A>C and C3 rs344550, G>C) in two complement genes were positively associated with marginal zone lymphoma (MZL) and C1QG was associated with CLL/SLL, but these results were based on a limited number of cases. Our results suggest a potential role of the complement system in susceptibility to NHL; however, our results should be viewed as exploratory and further replication is needed to clarify these preliminary findings.
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6
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