Hierarchical macro/micro-porous silk fibroin scaffolds for tissue engineering
Hierarchical macro/micro-porous silk fibroin scaffolds for tissue engineering
复制标题
用于组织工程的分层大孔/微孔丝素蛋白支架
DOI：
10.1016/j.matlet.2018.10.040
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发表时间：
2019
影响因子：
3
通讯作者：
Zhu Meifeng
中科院分区：
文献类型：
--
作者：
Du Lilong;Li Wen;Jiang Zhuyan;Wang Lianyong;Kong Deling;Xu Baoshan;Zhu Meifeng
具有层次结构的支架材料能够促进细胞的附着、增殖和引导组织的形成，一直是组织工程的主要目标之一。本文采用石蜡球浸提和相分离相结合的方法制备了丝素蛋白（SF）大/微孔支架。该支架具有可调节的大/微孔尺寸、连通的孔隙、高孔隙率和一定的力学性能。该支架还促进了细胞的附着、浸润和增殖，这可以是用于细胞递送和组织再生的理想候选物。
Scaffolds with hierarchical structures capable of promoting cells attachment, proliferation and guiding tissue formation have always been one of the major goals in tissue engineering. Here, a macro/micro-porous silk fibroin (SF) scaffold was fabricated by combining the paraffin sphere leaching and phase separation methods. The scaffolds possess adjustable macro/micro pores size, interconnected pores, high porosity and certain mechanical property. The scaffolds also promoted cell attachment, infiltration and proliferation, which can be an ideal candidate for cell delivery and tissue regeneration.