One-dimensional viscoelastic behavior of fibroblast populated collagen matrices.
One-dimensional viscoelastic behavior of fibroblast populated collagen matrices.
复制标题
成纤维细胞填充的胶原基质的一维粘弹性行为。
DOI：
10.1115/1.1614818
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Elson,ElliotL
中科院分区：
文献类型：
--
作者：
Wagenseil,JessicaE;Wakatsuki,Tetsuro;Okamoto,RuthJ;Zahalak,GeorgeI;Elson,ElliotL
生物人工组织正在被开发作为受损生物组织的替代品。它们的机械性能对于承载应用至关重要。目前生物人工组织的测试方案变化很大，并且通常不考虑粘弹性。对成纤维细胞填充的胶原基质（FPCM）进行单轴拉伸试验，以确定特定试验方案对机械性能的影响。峰值力、滞后和力-牵拉曲线的形状受牵拉速率、休息时间、牵拉振幅和预处理循环的数量和幅度的影响。
Bio-artificial tissues are being developed as replacements for damaged biologic tissues. Their mechanical properties are critical for load bearing applications. Current testing protocols for bio-artificial tissues vary widely and often do not consider viscoelasticity. Uniaxial stretch tests were performed on fibroblast populated collagen matrices (FPCMs) to determine the influence of specific test protocols on the mechanical behavior. The peak force, hysteresis and shape of the force-stretch curve are affected by the stretch rate, rest period, stretch amplitude and the number and magnitude of preconditioning cycles.