Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation.
Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation.
复制标题
DOI：
10.3390/ijms161226092
复制
发表时间：
2015-11-27
影响因子：
5.6
通讯作者：
Yamada K
中科院分区：
文献类型：
--
作者：
Ibi D;Yamada K
越来越多的流行病学证据表明，围产期感染各种病毒病原体会增加患多种精神疾病的风险。星形胶质细胞与神经元和/或肠道微生物组相互作用的病理生理学意义已被报道在产前和产后免疫损伤引发的神经发育障碍中。最近的研究与母亲的免疫激活或新生儿的多聚核糖肌苷酸多聚核糖胞苷酸模型的神经发育障碍已经确定了各种候选分子，可能是负责脑功能障碍。在这里，我们回顾了几个候选分子在神经发育和脑功能中的功能，并讨论了它们作为精神疾病治疗靶点的潜力。
Increasing epidemiological evidence indicates that perinatal infection with various viral pathogens enhances the risk for several psychiatric disorders. The pathophysiological significance of astrocyte interactions with neurons and/or gut microbiomes has been reported in neurodevelopmental disorders triggered by pre- and postnatal immune insults. Recent studies with the maternal immune activation or neonatal polyriboinosinic polyribocytidylic acid models of neurodevelopmental disorders have identified various candidate molecules that could be responsible for brain dysfunction. Here, we review the functions of several candidate molecules in neurodevelopment and brain function and discuss their potential as therapeutic targets for psychiatric disorders.