ASSOCIATION BETWEEN EXPLORATORY ACTIVITY AND SOCIAL INDIVIDUALITY IN GENETICALLY IDENTICAL MICE LIVING IN THE SAME ENRICHED ENVIRONMENT
ASSOCIATION BETWEEN EXPLORATORY ACTIVITY AND SOCIAL INDIVIDUALITY IN GENETICALLY IDENTICAL MICE LIVING IN THE SAME ENRICHED ENVIRONMENT
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DOI：
10.1016/j.neuroscience.2015.05.027
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发表时间：
2015-11-19
期刊：
影响因子：
3.3
通讯作者：
Kempermann, G.
中科院分区：
文献类型：
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作者：
Freund, J.;Brandmaier, A. M.;Kempermann, G.
我们之前曾报道，生活在一个丰富环境中的近亲繁殖的、基因相同的小鼠会发展出个体行为轨迹，这表明通过漫游熵来量化的空间探索行为的水平越来越不同。累积漫游熵(CRE)与成人海马神经发生呈正相关，海马神经发生是一种可塑性，涉及将新信息灵活整合到现有背景中(Freund等人，2013年)。我们在这里报道的研究与第一个实验是平行进行的，但在这里，我们获得了关于单个小鼠行为的详细观察数据。在整个3个月的实验期内，使用基于天线的系统再次实时评估漫游熵(RE)。与围栏中最不活跃的小鼠(触角接触次数较少)相比，最活跃的小鼠在最终观察区块中表现出更多的社交互动行为，而最不活跃的小鼠表现出更多的自我相关行为(非社会性局部探索和游戏)。当考察漫游行为时，我们发现RE与代表社会性探索和非社会性探索和游戏行为的潜在因素呈负相关。在目前的队列中不能研究成人的神经发生，但我们知道在相同的条件下，累积的RE与成人的海马神经发生呈正相关。因此，我们可以假设，在区域覆盖率(由RE量化)方面具有更多探索性经验的小鼠，以及相关的成年海马区可塑性更高水平的小鼠，可能也是那些较少参与组内互动的小鼠，因此，更具个人主义。虽然这一点仍有待实验证实，但目前的数据表明，先前被证明依赖于海马体的个性化机制具有社会成分。(C)2015年IBRO。爱思唯尔有限公司出版。保留所有权利。
We previously reported that inbred, genetically identical mice living in one enriched environment develop individual behavioral trajectories, indicating increasingly different levels of spatial exploratory behavior as quantified by roaming entropy. Cumulative roaming entropy (cRE) correlated positively with adult hippocampal neurogenesis, a type of plasticity involved in the flexible integration of new information into existing contexts (Freund et al., 2013). The study on which we report here was done in parallel to that first experiment, but here we acquired detailed observational data on the behavior of individual mice. Roaming entropy (RE) was again assessed in real-time with an antenna-based system over the entire experimental period of 3 months. Compared to the least active mice in the enclosure (low number of antenna contacts), the most active animals showed tendencies of increased socially interactive behavior in the final observation block whereas least active mice displayed more self-related behavior (non-social local exploration and play). When looking at roaming behavior, we discovered that RE correlated negatively with latent factors representing social exploratory and non-social exploratory and play behavior. Adult neurogenesis could not be studied in the present cohort but we do know that under identical conditions, cumulative RE correlated positively with adult hippocampal neurogenesis. We can thus hypothesize that the mice with more exploratory experience in terms of areal coverage (as quantified by RE) and related greater levels of adult hippocampal plasticity, might also be the ones that were less involved in interactions within the group and, hence, more individualistic. While this remains to be confirmed experimentally, the present data suggest that the described mechanism of individualization, which has previously been shown to be hippocampus-dependent, has a social component. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.