Heightened sensitivity to the disinhibiting effect of alcohol in women during the late follicular phase of the menstrual cycle.
Heightened sensitivity to the disinhibiting effect of alcohol in women during the late follicular phase of the menstrual cycle.
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在月经周期末卵泡期，女性对酒精的去抑制作用更加敏感。
DOI：
10.1037/pha0000611
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发表时间：
2023
影响因子：
2.3
通讯作者：
Fillmore,MarkT
中科院分区：
文献类型：
--
作者：
Griffith,AnnieK;Martel,MichelleM;Eisenlohr-Moul,Tory;Fillmore,MarkT
与男性相比，女性受到酒精的影响更大，包括更大的生理损伤、行为障碍和复发的风险。造成这种脆弱性的性别差异的一个可能机制是卵巢激素，特别是雌二醇（E2）在月经周期各个阶段的波动。多项临床前和临床研究表明，较高的 E2 水平与饮酒呈正相关，表明 E2 可能在调节饮酒方面发挥重要作用。抑制控制也可以调节饮酒。当酒精减少或损害酒精时，饮酒者停止自我饮酒的能力可能会受到损害，从而导致暴饮暴食。本研究旨在探讨月经周期阶段对酒精去抑制作用的影响程度。 24 名健康的年轻成年女性参加了一项受试者内安慰剂对照研究，研究 0.60 g/kg 酒精在两次测试过程中的急性去抑制作用。提示进行/不进行任务测量了在 E2 水平较低的周期早期卵泡期和 E2 水平升高的卵泡晚期（即排卵）期间酒精和安慰剂饮料的去抑制作用。结果表明，在卵泡晚期，当 E2 升高时，酒精的去抑制作用增加了近两倍。这些发现强调了酒精引起的抑制解除作为一种潜在的行为机制的作用，通过这种机制，卵巢激素的波动作为月经周期的函数，导致女性过度饮酒的风险增加。（PsycInfo 数据库记录 (c) 2023 APA，保留所有权利）
Compared with men, women are disproportionately affected by alcohol, including greater risks of physiological damage, behavioral impairment, and relapse. One likely mechanism underlying the sexual disparity in this vulnerability is the fluctuation of ovarian hormones, particularly estradiol (E2), across phases of the menstrual cycle. Several preclinical and clinical studies have shown that higher E2 levels positively correlate with drinking, suggesting E2 may play a significant role in modulating drinking. Inhibitory control also modulates drinking; when it is reduced or compromised by alcohol, the drinker’s ability to stop the self-administration of alcohol could be impaired, leading to a binge episode. The present study aimed to examine the degree to which menstrual cycle phase can influence the disinhibiting effect of alcohol. Twenty-four healthy young adult women participated in a within-subjects placebo-controlled study of the acute disinhibiting effect of 0.60 g/kg alcohol over the course of two test sessions. A cued go/no-go task measured the disinhibiting effects of alcohol and placebo beverages during the early follicular phase of the cycle when E2 levels were low and the late follicular phase (ie, ovulation) when E2 was elevated. Results showed that the disinhibiting effect of alcohol increased nearly twofold during the late follicular phase when E2 was elevated. These findings highlight the role of alcohol-induced disinhibition as a potential behavioral mechanism by which fluctuations in ovarian hormones as a function of the menstrual cycle contribute to increased risk for excessive alcohol use in women.(PsycInfo Database Record (c) 2023 APA, all rights reserved)