Synthesis of octacalcium phosphate with incorporated succinate and suberate ions
Synthesis of octacalcium phosphate with incorporated succinate and suberate ions
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掺入琥珀酸根和辛二酸根离子的磷酸八钙的合成
DOI：
10.1016/j.ceramint.2012.01.030
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发表时间：
2011
影响因子：
5.2
通讯作者：
Chikara Ohtsuki
中科院分区：
文献类型：
--
作者：
Taishi Yokoi;Hidetaka Kato;Ill Yong Kim;Koichi Kikuta;Masakazu Kawashita;Chikara Ohtsuki
磷酸八钙（OCP）具有由磷灰石层和水化层组成的层状结构。水合层中的HPO 42-可以被二羧酸根离子取代。研究了二羧酸初始浓度对磷酸八钙（octacalcium phosphate carboxylate，OCPC）形成的影响。以丁二酸（Suc）和辛二酸（Sub）为二元羧酸制备了OCPC，并利用X射线粉末衍射（XRD）对产物的晶相进行了表征。当添加的二羧酸的量是对应于OCPC的化学计量组成的量的1-5倍时，二羧酸根离子的掺入随着添加的二羧酸的量的增加而进行，尽管也存在没有掺入二羧酸根离子的OCP。当Suc和Sub的添加量大于OCPC化学计量量的10倍时，在粉末XRD图谱中检测到单一的OCPC相。Suc和Sub的量大于化学计量量的10倍促进OCPC的形成并抑制OCP的形成。二羧酸根离子与HPO 42 −竞争结合到OCP中。因此，需要高浓度的二羧酸以将二羧酸根离子完全掺入OCP中。
Octacalcium phosphate (OCP) has a layered structure composed of apatitic and hydrated layers. HPO42−in the hydrated layer can be substituted by dicarboxylate ions. The synthesis of octacalcium phosphate with incorporated dicarboxylate ions (octacalcium phosphate carboxylate, OCPC), was investigated through the effects of the initial concentration of dicarboxylic acid on the formation of OCPC. Succinic acid (Suc) and suberic acid (Sub) were used as dicarboxylic acids for preparing OCPC, and crystalline phases of the products were characterized by powder X-ray diffraction (XRD). When the amount of added dicarboxylic acid was 1–5 times the amount corresponding to the stoichiometric composition of OCPC, incorporation of dicarboxylate ions progressed with increasing amount of added dicarboxylic acids, although OCP without incorporated dicarboxylate ions was also present. When the amounts of added Suc and Sub were larger than 10 times the stoichiometric amount in OCPC, a single OCPC phase was detected in the powder XRD patterns. Amounts of Suc and Sub greater than 10 times the stoichiometric amounts facilitated formation of the OCPCs and inhibited formation of OCP. The incorporation of dicarboxylate ions into OCP competes with incorporation of HPO42−. Hence a high concentration of dicarboxylic acids is required for complete incorporation of dicarboxylate ions in OCP.