Visible-light-promoted synthesis of phenanthridines via an intermolecular isocyanide insertion reaction
Visible-light-promoted synthesis of phenanthridines via an intermolecular isocyanide insertion reaction
复制标题
可见光促进通过分子间异氰化物插入反应合成菲啶
DOI：
10.1039/c6ob02113a
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发表时间：
2016
影响因子：
3.2
通讯作者：
Tan Ren Xiang
中科院分区：
文献类型：
--
作者：
Zhou Hui;Deng Xin Zhao;Zhang Ai Hua;Tan Ren Xiang
An isocyanide insertion reaction promoted by the combination of an amide and a photoredox is now presented. By using visible light, 6-amidophenanthridine derivatives can be prepared in good chemical yields under mild and eco-friendly reaction conditions. The reaction was shown to proceed through an electron transfer sequence by mechanistic experiments, and thus enabled the efficient production of 24 compounds, each with one new intramolecular aromatic ring obtained. The synthesized compounds were tested to embody good antitumor, antimicrobial and neuraminidase inhibitory activities.
