Ethnic and Gender Related Differences in the Risk of End-Stage Renal Disease After Living Kidney Donation
Ethnic and Gender Related Differences in the Risk of End-Stage Renal Disease After Living Kidney Donation
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DOI：
10.1111/j.1600-6143.2011.03609.x
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发表时间：
2011-08-01
影响因子：
8.8
通讯作者：
Fan, P. -Y.
中科院分区：
文献类型：
--
作者：
Cherikh, W. S.;Young, C. J.;Fan, P. -Y.
关于活体肾脏捐献后患终末期肾病(ESRD)风险的数据有限。器官采购和移植网络以及医疗保险和医疗补助服务中心的数据库被用来识别随后患上ESRD的活体肾脏捐赠者(LKD)，并计算LKD ESRD率。在1987年10月1日至2003年3月31日期间捐献的56458例LKD患者中，发现ESRD患者126例(0.22%)。LKD终末期肾病的总体发病率为0.134/1000年，平均随访时间为9.8年。与普通人群中的ESRD发病率相比，LKD的总体和黑人、白人、男性和女性捐赠者的ESRD发生率更高。黑人的LKD ESRD发病率几乎是白人的五倍，男性是女性的两倍。然而，这些种族和性别相关的差异与以前报告的ESRD在普通人群中的差异相似。我们的研究结果没有显示LKD患者发生终末期肾病的风险增加，并支持目前活体肾脏捐赠的做法。需要进一步的研究来确定改进的供者筛选或随访是否会降低捐献后ESRD的风险。
There is limited data pertaining to the risk of End Stage Renal Disease (ESRD) after living kidney donation. The Organ Procurement and Transplantation Network and the Center for Medicare and Medicaid Services databases were used to identify living kidney donors (LKDs) who subsequently developed ESRD and to calculate LKD ESRD rates. We found 126 cases of ESRD among 56 458 LKDs (0.22%) who donated during October 1, 1987-March 31, 2003. The overall LKD ESRD rate was 0.134 per 1000 years at risk, with an average duration of follow-up of 9.8 years. ESRD rates for LKDs overall and for Black, White, male and female donors compared favorably to the ESRD incidence in the general population. The LKD ESRD rate was nearly five times higher for Blacks than forWhites and two times higher for males than females. However, these ethnic and gender-related differences were similar to those previously reported for ESRD in the general population. Our findings do not show an increase in the risk of ESRD for LKDs and support the current practice of living kidney donation. Further research is needed to determine if improved donor screening or follow-up will reduce the risk of postdonation ESRD.