PC13 embryonal carcinoma‐derived growth factor.
PC13 embryonal carcinoma‐derived growth factor.
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PC13 胚胎癌衍生生长因子。
DOI：
10.1002/j.1460-2075.1984.tb02240.x
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
C. Isacke
中科院分区：
文献类型：
--
作者：
J. Heath;C. Isacke
从PC13小鼠胚胎癌细胞培养的无血清培养基中分离出一种强效生长因子PC13胚胎癌源性生长因子（ECDGF）。ECDGF为单链阳离子疏水分子，分子量为17500道尔顿。ECDGF将在体外诱导成纤维细胞系和PC13 EC细胞的直接分化后代中诱导DNA合成，因此在结构和作用上似乎与其他已被充分表征的生长因子不同。
A potent growth factor, PC13 embryonal carcinoma‐derived growth factor (ECDGF), has been isolated from serum‐free medium conditioned by PC13 murine embryonal carcinoma cells. ECDGF is a single chain, cationic hydrophobic molecule of 17 500 daltons. ECDGF will induce DNA synthesis in established fibroblast cell lines and the immediate differentiated progeny of PC13 EC cells in vitro, and consequently appears to differ from other well characterised growth factors both in structure and action.