Accelerated Chemical Reactions and Organic Synthesis in Leidenfrost Droplets
Accelerated Chemical Reactions and Organic Synthesis in Leidenfrost Droplets
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DOI：
10.1002/anie.201605899
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发表时间：
2016-08-22
影响因子：
16.6
通讯作者：
Cooks, R. Graham
中科院分区：
文献类型：
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作者：
Bain, Ryan M.;Pulliam, Christopher J.;Cooks, R. Graham
莱顿弗罗斯特悬浮液滴可用于加速过程中的化学反应，该过程类似于电喷雾电离产生的带电微滴中的反应加速。在莱顿弗罗斯特液滴的反应加速证明了碱催化的Claisen-Schmidt缩合，从预充电和中性酮的腙形成，并在各种反应条件下的Katritzky pyrylium到吡啶的转化。与本体反应的比较给出了中间加速因子（2 - 50）。通过保持Leidenfrost液滴的体积恒定，结果表明，界面效应有助于加速;这通过在表面活性剂存在下反应速率降低来证实。多重Leidenfrost微反应器的能力，在反应过程中提取产品到不混溶的溶剂中，并使用Leidenfrost液滴作为反应容器来合成毫克量的产品也被证明。
Leidenfrost levitated droplets can be used to accelerate chemical reactions in processes that appear similar to reaction acceleration in charged microdroplets produced by electrospray ionization. Reaction acceleration in Leidenfrost droplets is demonstrated for a base-catalyzed Claisen-Schmidt condensation, hydrazone formation from precharged and neutral ketones, and for the Katritzky pyrylium into pyridinium conversion under various reaction conditions. Comparisons with bulk reactions gave intermediate acceleration factors (2-50). By keeping the volume of the Leidenfrost droplets constant, it was shown that interfacial effects contribute to acceleration; this was confirmed by decreased reaction rates in the presence of a surfactant. The ability to multiplex Leidenfrost microreactors, to extract product into an immiscible solvent during reaction, and to use Leidenfrost droplets as reaction vessels to synthesize milligram quantities of product is also demonstrated.