Improved synthetic routes to methylene-bridged P-chiral diphosphine ligands via secondary phosphine-boranes
Improved synthetic routes to methylene-bridged P-chiral diphosphine ligands via secondary phosphine-boranes
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DOI：
10.1016/j.tetasy.2010.03.025
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发表时间：
2010-06-23
影响因子：
--
通讯作者：
Sugiya, Masashi
中科院分区：
文献类型：
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作者：
Imamoto, Tsuneo;Tamura, Ken;Sugiya, Masashi
描述了制备亚甲基桥连双膦配体的改进方法。关键中间体叔丁基甲基膦-硼烷的两种对映异构体通过拆分或通过将一种对映异构体转化为相反的对映异构体来制备。以良好的产率和对映体纯的形式制备了双（叔丁基甲基膦基）甲烷（t-Bu-MiniPHOS）、双（（1，1，3，3-四甲基丁基）甲基膦基）甲烷（t-Oct-MiniPHOS）和（叔丁基甲基膦基）（二叔丁基膦基）甲烷（trichickenfootphos）的前体硼烷配合物。(C)2010爱思唯尔有限公司版权所有。
Improved methods for the preparation of methylene-bridged diphosphine ligands are described. Both enantiomers of the key intermediate tert-butylmethylphosphine-borane were prepared via resolution or by the conversion of one enantiomer into the opposite enantiomer. The precursor borane complexes of bis (tert-butylmethylphosphino)methane (t-Bu-MiniPHOS), bis((1,1,3,3-tetramethylbutyl)methylphosphino)methane (t-Oct-MiniPHOS), and (tert-butylmethylphosphino)(di-tert-butylphosphino)methane (trichickenfootphos) were prepared in good yields and enantiopure form. (C) 2010 Elsevier Ltd. All rights reserved.