Modulation of monoamine transporter expression and function by repetitive transcranial magnetic stimulation
Modulation of monoamine transporter expression and function by repetitive transcranial magnetic stimulation
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DOI：
10.1016/j.bbrc.2004.12.009
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发表时间：
2005-02-04
影响因子：
3.1
通讯作者：
Nukina, N
中科院分区：
文献类型：
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作者：
Ikeda, T;Kurosawa, M;Nukina, N
重复经颅磁刺激（rTMS）是一种治疗神经精神疾病的新手段。然而，rTMS的作用机制尚不清楚。在这项研究中，我们分析了单胺转运蛋白（MAT）基因的mRNA表达变化，该基因是抗抑郁药和精神兴奋剂的靶点。经过20天的rTMS治疗后，发现这些基因在小鼠大脑中有差异表达。慢性rTMS后观察到血清素转运体（SERT） mRNA水平下调，随后血清素摄取和结合减少。与SERT变化相反，观察到多巴胺转运蛋白（DAT）和去甲肾上腺素转运蛋白（NET） mRNA水平升高。对于NET，而不是DAT，在摄取和结合方面也有相应的变化。在rTMS刺激PC12细胞15天后，也观察到类似的NET效应。这些结果表明，慢性rTMS对MATs的调节可能是治疗神经精神疾病的一种治疗机制。(C) 2004爱思唯尔公司版权所有。
Repetitive transcranial magnetic stimulation (rTMS) is a new tool for the treatment of neuropsychiatric disorders. However, the mechanisms underlying the effects of rTMS are still unclear. In this study, we analyzed mRNA expression changes of monoamine transporter (MAT) genes, which are targets for antidepressants and psycho stimulants. Following a 20-day rTMS treatment, these genes were found to be differentially expressed in the mouse brain. Down-regulation of serotonin transporter (SERT) mRNA levels and the subsequent decrease in serotonin uptake and binding were observed after chronic rTMS. In contrast to the SERT changes, increased mRNA levels of dopamine transporter (DAT) and norepinephrine transporter (NET) were observed. For NET, but not DAT, there were accompanying changes in uptake and binding. Similar effect on NET was observed in PC12 cells stimulated by rTMS for 15 days. These results indicate that modulation of MATs by chronic rTMS may be one therapeutic mechanism for the treatment of neuropsychiatric disorders. (C) 2004 Elsevier Inc. All rights reserved.