5-HYDROXYTRYPTAMINE STIMULATES THE FORMATION OF INOSITOL PHOSPHATE IN ASTROCYTES FROM DIFFERENT REGIONS OF THE BRAIN
5-HYDROXYTRYPTAMINE STIMULATES THE FORMATION OF INOSITOL PHOSPHATE IN ASTROCYTES FROM DIFFERENT REGIONS OF THE BRAIN
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DOI：
10.1016/0028-3908(87)90102-x
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发表时间：
1987-09-01
影响因子：
4.7
通讯作者：
ALLING, C
中科院分区：
文献类型：
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作者：
HANSSON, E;SIMONSSON, P;ALLING, C
5-羟色胺（5-HT）刺激原代培养的大脑皮层、纹状体、海马和脑干星形胶质细胞磷酸肌醇的周转。酮色林和利坦色林，中枢5-HT 2受体的选择性拮抗剂，抑制5-HT刺激的肌醇一磷酸的形成。与此相反，有没有统计学上显着的积累后，与不同浓度的5-HT培养的任何文化研究的环AMP。结果表明，来自大脑不同区域的星形胶质细胞具有与肌醇磷酸形成偶联的5-HT 2受体。
5-Hydroxytryptamine (5-HT) stimulated the turnover of phosphoinositide in primary cultures of astroglia form the cerebral cortex, striatum, hippocampus and brain stem. Ketanserin and ritanserin, selective antagonists for the central 5-HT2 receptor, inhibited the 5-HT-stimulated formation of inositol monophosphate. In contrast, there was no statistically significant accumulation of cyclic AMP after incubation with different concentrations of 5-HT any of the cultures studied. The results indicate that astrocytes from various regions of the brain possess 5-HT2 receptors coupled to the formation of inositol phosphates.