Lactobacillus Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens.
Lactobacillus Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens.
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DOI：
10.1128/msphere.00061-18
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发表时间：
2018-05
期刊：
影响因子：
4.8
通讯作者：
Dean GA
中科院分区：
文献类型：
--
作者：
LeCureux JS;Dean GA
自20世纪90年代以来，乳酸菌（LAB）已被用于治疗性异源基因表达。LAB引发针对表达的外源抗原的免疫应答的能力已经导致其作为潜在的粘膜疫苗候选物的探索。自20世纪90年代以来，乳酸菌（LAB）已被用于治疗性异源基因表达。LAB引发针对表达的外源抗原的免疫应答的能力已经导致其作为潜在的粘膜疫苗候选物的探索。LAB疫苗载体提供了许多有吸引力的优点：简单，非侵入性给药（通常是口服或鼻内），遗传修饰的可接受性和稳定性，相对较低的成本，以及最高水平的安全性。近年来，使用乳酸杆菌属的LAB的实验变得流行，因为它们能够引起强烈的全身和粘膜免疫应答。本文综述了乳杆菌疫苗的构建，包括乳杆菌的种类，抗原表达，模式生物，和体内免疫反应，主要集中在病毒和细菌抗原。
Lactic acid bacteria (LAB) have been utilized since the 1990s for therapeutic heterologous gene expression. The ability of LAB to elicit an immune response against expressed foreign antigens has led to their exploration as potential mucosal vaccine candidates. Lactic acid bacteria (LAB) have been utilized since the 1990s for therapeutic heterologous gene expression. The ability of LAB to elicit an immune response against expressed foreign antigens has led to their exploration as potential mucosal vaccine candidates. LAB vaccine vectors offer many attractive advantages: simple, noninvasive administration (usually oral or intranasal), the acceptance and stability of genetic modifications, relatively low cost, and the highest level of safety possible. Experimentation using LAB of the genus Lactobacillus has become popular in recent years due to their ability to elicit strong systemic and mucosal immune responses. This article reviews Lactobacillus vaccine constructs, including Lactobacillus species, antigen expression, model organisms, and in vivo immune responses, with a primary focus on viral and bacterial antigens.