Theoretical Biology and Medical Modelling Open Access Homeostatic Mechanisms in Dopamine Synthesis and Release: a Mathematical Model
Theoretical Biology and Medical Modelling Open Access Homeostatic Mechanisms in Dopamine Synthesis and Release: a Mathematical Model
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通讯作者：
Janet A Best;Frederik H. Nijhout;Michael C;Reed
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作者：
Janet A Best;Frederik H. Nijhout;Michael C;Reed
背景：多巴胺是一种儿茶酚胺，在外周和中枢神经系统中都被用作神经递质。众所周知，各种多巴胺能系统的功能障碍与各种疾病有关，包括精神分裂症、帕金森病和多发性抽动症。此外，微透析研究表明，上瘾药物会增加细胞外多巴胺，脑成像显示欣快感与精神兴奋剂诱导的细胞外多巴胺增加之间存在相关性[1]。多巴胺功能障碍的这些后果表明，通过平衡机制维持多巴胺功能的重要性，这种平衡机制被归因于合成、储存、释放、代谢和再摄取之间的微妙平衡。
Background: Dopamine is a catecholamine that is used as a neurotransmitter both in the periphery and in the central nervous system. Dysfunction in various dopaminergic systems is known to be associated with various disorders, including schizophrenia, Parkinson's disease, and Tourette's syndrome. Furthermore, microdialysis studies have shown that addictive drugs increase extracellular dopamine and brain imaging has shown a correlation between euphoria and psycho-stimulant-induced increases in extracellular dopamine [1]. These consequences of dopamine dysfunction indicate the importance of maintaining dopamine functionality through homeostatic mechanisms that have been attributed to the delicate balance between synthesis, storage, release, metabolism, and reuptake.