Quantifying regional hypoxia in human tumors with positron emission tomography of [F-18]fluoromisonidazole: A pretherapy study of 37 patients
Quantifying regional hypoxia in human tumors with positron emission tomography of [F-18]fluoromisonidazole: A pretherapy study of 37 patients
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DOI：
10.1016/s0360-3016(96)00325-2
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发表时间：
1996-09-01
影响因子：
7
通讯作者：
Krohn, KA
中科院分区：
文献类型：
--
作者：
Rasey, JS;Koh, WJ;Krohn, KA
目的：在注射缺氧结合放射性药物[F-18]氟咪唑后，使用正电子发射断层扫描（PET）评估各种肿瘤的预处理缺氧（[F-18]FMISO）.方法和材料：测定了21例非小细胞肺癌、7例头颈癌、4例前列腺癌、5例其他恶性肿瘤患者注射[F-18]FMISO（0.1mCi/kg）后进行定量PET显像。FHV定义为注射后120-160 min时成像肿瘤体积中组织：血液[F-18]活性比大于或等于1.4的像素比例。结果：37例肿瘤中有36例可见乏氧，FHV为0 ~ 94.7%。在非小细胞肺癌（n = 21）中，中位FHV为47.6%，范围为1.3 - 94.7%。肿瘤大小与FHV无相关性。在7例头颈部癌中，中位PW为8.8%，范围为0.2%至18.9%。在四个前列腺癌组中，中位数和范围为18.2%和0至93.9%，而在一组的五个不同类型的肿瘤的中位数FHV为55.2%（范围：21.4至85.8%）。结论：缺氧是存在于97%的肿瘤研究和缺氧的程度不同的肿瘤在同一地点或相同的组织学显着。缺氧在单个肿瘤内的区域之间也是不均匀分布的。这些结果与其他类型的人类肿瘤的O-2电极测量结果一致。肿瘤内和肿瘤间的变异性表明在个体肿瘤中进行氧合测量的重要性以及尽可能多地对肿瘤体积进行采样的必要性。版权所有O 1996 Elsevier Science Inc.
Purpose: To assess pretreatment hypoxia in a variety of tumors using positron emission tomography (PET) after injection of the hypoxia-binding radiopharmaceutical [F-18]fluoromisonidazole ([F-18]FMISO).Methods and Materials: Tumor fractional hypoxic volume (FHV) was determined in 21 nonsmall cell lung cancer patients, 7 head and neck cancer patients, 4 prostate cancer patients, and 5 patients with other malignancies by quantitative PET imaging after injection of [F-18]FMISO (0.1 mCi/kg). The FHV was defined as the proportion of pixels in the imaged tumor volume with a tissue:blood [F-18] activity ratio greater than or equal to 1.4 at 120-160 min postinjection. A FHV > 0 was taken as evidence for tumor hypoxia.Results: Hypoxia was observed in 36 of 37 tumors studied with FMISO PET imaging; FHVs ranged from 0 to 94.7%. In nonsmall cell lung cancers (n = 21), the median FHV was 47.6% and the range, 1.3 to 94.7%. There was no correlation between tumor size and FHV. In the seven head and neck carcinomas, the median PW was 8.8%, with a range from 0.2 to 18.9%. In the group of four prostate cancers, the median and range were 18.2% and 0 to 93.9%, while in a group of five tumors of different types the median FHV was 55.2% (range: 21.4 to 85.8%).Conclusions: Hypoxia was present in 97% of the tumors studied and the extent of hypoxia varied markedly between tumors in the same site or of the same histology. Hypoxia also was distributed heterogeneously between regions within a single tumor. These results are consistent with O-2 electrode measures with other types of human tumors. The intra- and intertumor variability indicate the importance of making oxygenation measures in individual tumors and the necessity to sample as much of the tumor volume as possible. Copyright O 1996 Elsevier Science Inc.