Solid dispersion melt crystallization (SDMC) concept using binary eutectic system for improvement of dissolution rate
Solid dispersion melt crystallization (SDMC) concept using binary eutectic system for improvement of dissolution rate
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DOI：
10.1016/j.jiec.2021.05.032
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发表时间：
2021-05
影响因子：
6.1
通讯作者：
Kentaro Atsukawa;S. Amari;H. Takiyama
中科院分区：
文献类型：
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作者：
Kentaro Atsukawa;S. Amari;H. Takiyama
从产品设计和工业流程的角度来看，目标材料的溶解度是最有价值的品质之一。我们提出了固体分散熔融结晶(SDMC)的概念，这是一种新颖的将目标材料分散在基质材料中的策略，即目标材料自然地分散在由首先析出的基质材料形成的缝隙之间。此外，通过一个二元共晶体系考察了在SDMC概念中引入冷却、搅拌和曝气等操作对溶解速率的影响。实验结果表明，通过冷却、搅拌和曝气等操作可以提高其溶出速度。溶解速度的提高归功于基于SDMC概念的成核速率的提高。由此可见，SDMC概念提高了成核速率，有效地提高了溶出度。
From the designs of product and industrial process perspectives, the solubility of a target material is one of the most valuable qualities. We proposed the ‘solid dispersion melt crystallization (SDMC) concept’ as a original strategy for dispersing a target material in a matrix one, in which the target material is naturally dispersed between the crevices formed by the matrix material precipitated first. Furthermore, the effects of introducing some operations, such as cooling, agitation and aeration, to the SDMC concept on the dissolution rate were investigated by a binary eutectic system. According to the experimental results, the dissolution rate was enhanced by the operations (cooling, agitation and aeration). This improvement in the dissolution rate was attributed to the SDMC concept-based enhancement of the nucleation rate. Therefore, it was revealed that an increase in the nucleation rate due to the SDMC concept had effectively improved the dissolution rate.