G2Cdb: the Genes to Cognition database.
G2Cdb: the Genes to Cognition database.
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G2CDB：认知数据库的基因。
DOI：
10.1093/nar/gkn700
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发表时间：
2009-01
影响因子：
14.9
通讯作者：
Grant SG
中科院分区：
文献类型：
--
作者：
Croning MD;Marshall MC;McLaren P;Armstrong JD;Grant SG
神经科学数据库将跨物种的基因、蛋白质、（病理）生理学、解剖学和行为学联系起来，这在神经系统的广泛研究中将是有价值的。G2Cdb就是这样一个神经科学数据库，旨在提供突触蛋白在生理学和疾病中作用的全局视图。G2Cdb仓库的基因和蛋白质组实验阐明的信号复合物和蛋白质的蛋白质组质谱生化分离哺乳动物突触制剂，给出了实验验证的定义的哺乳动物突触的组成部分。使用自动文本挖掘和专家（人）策展，我们系统地提取信息，从已发表的神经生物学研究领域的突触信号电生理学和行为基因敲除和其他转基因小鼠。我们还调查了人类遗传学文献中突触基因突变与疾病的关系。G2Cdb提供的突触蛋白质组数据集为突触生物学的未来工作提供了基础，并提供了有关大脑疾病的有用信息。它们以这样一种方式被整合，研究人员可以快速查询一个基因或蛋白质是否存在于脑信号复合物中，是否在啮齿动物模型中具有表型，或者突变是否与人类疾病有关。G2Cdb可以在http://www.genes2cognition.org上免费访问。
Neuroscience databases linking genes, proteins, (patho)physiology, anatomy and behaviour across species will be valuable in a broad range of studies of the nervous system. G2Cdb is such a neuroscience database aiming to present a global view of the role of synapse proteins in physiology and disease. G2Cdb warehouses sets of genes and proteins experimentally elucidated by proteomic mass spectroscopy of signalling complexes and proteins biochemically isolated from mammalian synapse preparations, giving an experimentally validated definition of the constituents of the mammalian synapse. Using automated text-mining and expert (human) curation we have systematically extracted information from published neurobiological studies in the fields of synaptic signalling electrophysiology and behaviour in knockout and other transgenic mice. We have also surveyed the human genetics literature for associations to disease caused by mutations in synaptic genes. The synapse proteome datasets that G2Cdb provides offer a basis for future work in synapse biology and provide useful information on brain diseases. They have been integrated in a such way that investigators can rapidly query whether a gene or protein is found in brain-signalling complex(es), has a phenotype in rodent models or whether mutations are associated with a human disease. G2Cdb can be freely accessed at http://www.genes2cognition.org.
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影响因子：
14.9
作者：
UniProt Consortium
通讯作者：
UniProt Consortium
影响因子：
14.9
作者：
Bruford, Elspeth A.;Lush, Michael J.;Wright, Mathew W.;Sneddon, Tam P.;Povey, Sue;Birney, Ewan
通讯作者：
Birney, Ewan
影响因子：
9.8
作者：
Magdaleno S;Jensen P;Brumwell CL;Seal A;Lehman K;Asbury A;Cheung T;Cornelius T;Batten DM;Eden C;Norland SM;Rice DS;Dosooye N;Shakya S;Mehta P;Curran T
通讯作者：
Curran T
影响因子：
14.9
作者：
Flicek P;Aken BL;Beal K;Ballester B;Caccamo M;Chen Y;Clarke L;Coates G;Cunningham F;Cutts T;Down T;Dyer SC;Eyre T;Fitzgerald S;Fernandez-Banet J;Gräf S;Haider S;Hammond M;Holland R;Howe KL;Howe K;Johnson N;Jenkinson A;Kähäri A;Keefe D;Kokocinski F;Kulesha E;Lawson D;Longden I;Megy K;Meidl P;Overduin B;Parker A;Pritchard B;Prlic A;Rice S;Rios D;Schuster M;Sealy I;Slater G;Smedley D;Spudich G;Trevanion S;Vilella AJ;Vogel J;White S;Wood M;Birney E;Cox T;Curwen V;Durbin R;Fernandez-Suarez XM;Herrero J;Hubbard TJ;Kasprzyk A;Proctor G;Smith J;Ureta-Vidal A;Searle S
通讯作者：
Searle S
影响因子：
14.9
作者：
Safran, M;Chalifa-Caspi, V;Lancet, D
通讯作者：
Lancet, D