p53 gene mutation and MDM2 overexpression in a case of primary malignant fibrous histiocytoma of the jejunum
p53 gene mutation and MDM2 overexpression in a case of primary malignant fibrous histiocytoma of the jejunum
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原发性空肠恶性纤维组织细胞瘤p53基因突变及MDM2过表达1例
DOI：
10.1034/j.1600-0463.2002.100207.x
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发表时间：
2002
期刊：
影响因子：
2.8
通讯作者：
Tsukasa Sato
中科院分区：
文献类型：
--
作者：
Y. Jiao;Shin‐ichi Nakamura;T. Sugai;W. Habano;N. Uesugi;Moriyasu Oikawa;Tsukasa Sato
胃肠道原发性恶性纤维组织细胞瘤极为罕见。迄今为止，英文文献中仅报道了 10 例发生于小肠的原发性恶性纤维组织细胞瘤。我们在此描述空肠中出现的原发性恶性纤维组织细胞瘤的遗传改变和形态学特征。免疫组织化学显示，肿瘤细胞表达波形蛋白、CD68 和 α-1-抗胰蛋白酶，但其他标记物呈阴性。在超微结构上，它们显示出成纤维细胞和组织细胞的特征。观察到 p53 和 MDM2 的免疫组织化学过度表达。 p53基因突变分析检测到外显子158密码子存在错义突变。我们的结果表明p53基因突变和MDM2过表达可能在肿瘤发生中发挥重要作用。据我们所知，本报告是对这种罕见病变的第一份基因研究。
Primary malignant fibrous histiocytoma of the gastrointestinal tract is extremely rare. To date, only 10 cases of primary malignant fibrous histiocytoma arising in the small intestine have been reported in the English literature. We describe here the genetic alterations and morphologic features of a primary malignant fibrous histiocytoma arising in the jejunum. Immunohistochemically, the tumor cells expressed vimentin, CD68 and α‐1‐antitrypsin, but were negative for other markers. Ultrastructurally, they showed features of fibroblasts and histiocytes. Immunohistochemical overexpression of p53 and MDM2 was observed. Mutation analysis of the p53 gene detected a missense mutation in codon 158 of exon 5. Our results suggest that p53 gene mutations and MDM2 overexpression may play an important role in the tumorigenesis. To our knowledge, the present report is the first genetic study of this rare lesion.
影响因子：
11.2
作者：
C. Cordon-Cardo;E. Latres;M. Drobnjak;M. R. Oliva;D. Pollack;J. Woodruff;V. Maréchal;Jiandong Chen;Murray F. Brennan;A. Levine
通讯作者：
C. Cordon-Cardo;E. Latres;M. Drobnjak;M. R. Oliva;D. Pollack;J. Woodruff;V. Maréchal;Jiandong Chen;Murray F. Brennan;A. Levine
影响因子：
10.5
作者：
WU, XW;BAYLE, JH;LEVINE, AJ
通讯作者：
LEVINE, AJ
DOI：
10.1073/pnas.95.26.15608
发表时间：
1998-12-22
影响因子：
11.1
作者：
Jones, SN;Hancock, AR;Bradley, A
通讯作者：
Bradley, A