Is There an ACE ID-ACTN3 R577X Polymorphisms Interaction that Influences Sprint Performance?
Is There an ACE ID-ACTN3 R577X Polymorphisms Interaction that Influences Sprint Performance?
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DOI：
10.1055/s-0029-1238291
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发表时间：
2009-12-01
影响因子：
2.5
通讯作者：
Meckel, Y.
中科院分区：
文献类型：
--
作者：
Eynon, N.;Alves, A. J.;Meckel, Y.
α-辅肌动蛋白3（ACTN 3）和血管紧张素转换酶（ACE）基因的功能性R577 X（rs.1815739）和ID（rs.5186）多态性分别与短跑成绩相关。本研究的目的是确定它们对81名以色列短跑运动员和240名健康对照组短跑成绩的影响。结果表明，ACE Ⅱ基因型+ACTN 3 R等位基因（P=0.003）和ACTN 3 RR基因型+ACE Ⅰ等位基因（P=0.001）可能是短跑运动员的基因型。在整个队列中，ACTN 3 RR基因型+ ACE I等位基因为短跑运动员的概率（OR 2.67，95%CI 1.45-4.93）和ACE II基因型+ACFN 3 R等位基因为短跑运动员的概率（OR 3.57，95%CI 1.78-7.15）显著高于对照组。总之，上述数据表明ACE ID/ACTN 3 R577 X基因型组合与短跑能力相关。然而，ACE ID/ACTN 3 R577 X基因型组合与性能水平无关。
Functional R577X (rs.1815739) and ID (rs.5186) polymorphisms in the alpha-actinin-3 (ACTN3) and the angiotensin converting enzyme (ACE) genes, respectively, have been associated with sprint performance. The aim of this study was to determine their effect on sprint performance among 81 Israeli sprinters and 240 healthy controls. Results revealed that the ACE II genotype + ACTN3 R allele (P=0.003 for sprinters vs. controls), and the ACTN3 RR genotype+ACE I allele (P=0.001 for sprinters vs. controls) might be the genotype for sprinters. In the whole cohort the probability of ACTN3 RR genotype + ACE I allele being a sprinter (odds ratio 2.67, 95% confidence interval 1.45-4.93) and of ACE II genotype + ACFN3 R allele being a sprinter (odds ratio 3.57, 95% confidence interval 1.78-7.15) was significantly higher than that in the controls. in conclusion, the above data suggest that ACE ID/ACTN3 R577X genotype combination is associated with sprint ability. However, ACE ID/ACTN3 R577X genotype combination is not related to the level of performance.