Two-Year Scale-Up of Seasonal Malaria Chemoprevention Reduced Malaria Morbidity among Children in the Health District of Koutiala, Mali.
Two-Year Scale-Up of Seasonal Malaria Chemoprevention Reduced Malaria Morbidity among Children in the Health District of Koutiala, Mali.
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DOI：
10.3390/ijerph17186639
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发表时间：
2020-09-11
影响因子：
--
通讯作者：
Djimde AA
中科院分区：
文献类型：
--
作者：
Maiga H;Gaudart J;Sagara I;Diarra M;Bamadio A;Djimde M;Coumare S;Sangare B;Dicko Y;Tembely A;Traore D;Dicko A;Lasry E;Doumbo O;Djimde AA
背景资料：以前的对照研究表明，季节性疟疾化学预防（SMC）可使3-59个月儿童的疟疾发病率降低80%以上。在此，我们评估了在马里库蒂亚拉卫生区开展试点活动期间大规模实施SMC后的疟疾发病率。方法：从2012年8月开始，儿童接受了三轮SMC，使用磺胺嘧啶-乙胺嘧啶（SP）和阿莫地喹（AQ）。从2013年7月起，儿童接受了四轮SMC。在2012年8月和2014年6月进行的两次横断面调查期间，评估了疟疾感染、临床疟疾和贫血的患病率。2012年的调查涉及20个随机选择的集群，2014年为10个集群。结果：总体而言，2012年纳入了662名儿童，2014年纳入了670名儿童。与2012年调查的儿童相比，2014年的儿童疟疾感染比例（2014年为12.4%，2012年为28.7%（p = 0.001））、临床疟疾比例（分别为0.3%和4.2%（p < 0.001））和贫血比例（分别为50.1%和67.4%（p = 0.001））均有所下降。考虑环境差异的倾向评分方法表明，SMC对疟疾感染具有显着的保护作用（IR = 0.01，95%CI（0.0001; 0.09），临床疟疾（OR = 0.25，95%CI（0.06; 0.85））和血红蛋白浓度（β = 1.3，95%CI（0.69; 1.96））。结论：SMC在库蒂亚拉扩大后两年内显著降低了疟疾感染、临床疟疾和贫血的频率。
Background: Previous controlled studies demonstrated seasonal malaria chemoprevention (SMC) reduces malaria morbidity by >80% in children aged 3–59 months. Here, we assessed malaria morbidity after large-scale SMC implementation during a pilot campaign in the health district of Koutiala, Mali. Methods: Starting in August 2012, children received three rounds of SMC with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ). From July 2013 onward, children received four rounds of SMC. Prevalence of malaria infection, clinical malaria and anemia were assessed during two cross-sectional surveys conducted in August 2012 and June 2014. Investigations involved 20 randomly selected clusters in 2012 against 10 clusters in 2014. Results: Overall, 662 children were included in 2012, and 670 in 2014. Children in 2014 versus those surveyed in 2012 showed reduced proportions of malaria infection (12.4% in 2014 versus 28.7% in 2012 (p = 0.001)), clinical malaria (0.3% versus 4.2%, respectively (p < 0.001)), and anemia (50.1% versus 67.4%, respectively (p = 0.001)). A propensity score approach that accounts for environmental differences showed that SMC conveyed a significant protective effect against malaria infection (IR = 0.01, 95% CI (0.0001; 0.09), clinical malaria (OR = 0.25, 95% CI (0.06; 0.85)), and hemoglobin concentration (β = 1.3, 95% CI (0.69; 1.96)) in 2012 and 2014, respectively. Conclusion: SMC significantly reduced frequency of malaria infection, clinical malaria and anemia two years after SMC scale-up in Koutiala.
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影响因子：
6.4
作者：
BEADLE, C;MCELROY, PD;HOFFMAN, SL
通讯作者：
HOFFMAN, SL
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Cissé, B;Sokhna, C;Trape, JF
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Trape, JF
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Bojang, Kalifa A.;Akor, Francis;Greenwood, Brian
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Greenwood, Brian
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Issiaka, Djibrilla;Barry, Amadou;Dicko, Alassane
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Dicko, Alassane
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3.7
作者：
Maiga H;Lasry E;Diarra M;Sagara I;Bamadio A;Traore A;Coumare S;Bahonan S;Sangare B;Dicko Y;Diallo N;Tembely A;Traore D;Niangaly H;Dao F;Haidara A;Dicko A;Doumbo OK;Djimde AA
通讯作者：
Djimde AA