HyperIgEaemia in patients with juvenile muscular atrophy of the distal upper extremity (Hirayama disease)
HyperIgEaemia in patients with juvenile muscular atrophy of the distal upper extremity (Hirayama disease)
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青少年上肢远端肌萎缩症（平山病）患者的高 IgE 血症
DOI：
10.1136/jnnp.2003.031609
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Takamichi Hattori
中科院分区：
文献类型：
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作者：
S. Ito;Satoshi Kuwabara;Toshio Fukutake;Y. Tokumaru;Takamichi Hattori
背景资料：幼年型上肢远端肌萎缩症（平山病）的特征是下颈髓前角细胞丢失，推测是由于颈部屈曲时硬脊膜囊向前移位所致。最近的一份报告表明，特应性和IgE可能有助于前角损伤。目的：探讨IgE是否是平山病的致病因素。研究方法：检测了20例连续患者的血清总IgE和过敏原特异性IgE，并研究了其与临床特征的相关性。结果：仅4例（20%）患者有既往或现病史，但14例（70%）患者血清IgE升高。高IgE血症患者比无高IgE血症患者有更严重的临床残疾（p = 0.01）。 在平山病病史少于5年的患者中，血清总IgE高于5年或5年以上的患者（p = 0.05）。 结论：结果表明，高IgE血症往往与平山病，并可以促进其病理生理，特别是在疾病的早期阶段。高IgE血症似乎不主要累及前角细胞。
Background: Juvenile muscular atrophy of the distal upper extremity (Hirayama disease) is characterised by anterior horn cell loss in the lower cervical cord, presumably caused by anterior displacement of the dural sac during neck flexion. A recent report suggests that atopy and IgE may contribute to anterior horn damage. Objective: To investigate whether IgE is a contributing factor in Hirayama disease. Methods: Serum total IgE and allergen specific IgE were examined in 20 consecutive patients, and their correlations with clinical profiles investigated. Results: Past or present history of allergy/atopy was found in only four patients (20%), but serum IgE was raised in 14 (70%). Patients with hyperIgEaemia had more severe clinical disabilities than those without (p = 0.01). In patients whose history of Hirayama disease was less than five years, serum total IgE was higher than in those with the disease for five years or more (p = 0.05). Conclusions: The results suggest that hyperIgEaemia is often associated with Hirayama disease and can facilitate its pathophysiology, particularly in the early phases of the disease. HyperIgEaemia does not appear to involve the anterior horn cells primarily.
日本学童中日本柳杉花粉病的流行情况。
DOI：
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发表时间：
2002
期刊：
Int Arch Allergy Immunol 128巻・2号
影响因子：
--
作者：
Ozasa K;Dejima K;Takenaka H
通讯作者：
Takenaka H