Glomerular hyperfiltration in hypertensive African Americans
Glomerular hyperfiltration in hypertensive African Americans
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DOI：
10.1161/01.hyp.35.3.822
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发表时间：
2000-03-01
期刊：
影响因子：
8.3
通讯作者：
Roman, RJ
中科院分区：
文献类型：
--
作者：
Kotchen, TA;Piering, AW;Roman, RJ
在非裔美国人中，高血压导致的终末期肾病的发病率是白人的5倍。为了确定肾小球超滤是否是肾衰竭的先兆，我们比较了肾血流和肾小球滤过率对去甲肾上腺素（0.01、0.025和0.05 μ g . kg（-1）。29名非裔美国人和33名年龄匹配的法裔加拿大白人原发性高血压患者。肾血流量和肾小球滤过率分别通过使用PAH和菊粉的恒定输注技术测量。研究在住院临床研究中心进行，降压药物已停用至少1周。根据24小时血压监测，夜间血压下降（P
The incidence of end-stage renal disease attributable to hypertension is 5-fold greater in African Americans than in whites. To determine whether glomerular hyperfiltration is an antecedent to renal failure, we compared responses of renal blood flow and glomerular filtration rate to graded infusions of norepinephrine (0.01, 0.025, and 0.05 mu g . kg(-1) . min(-1) for 30 minutes each) in 29 African Americans and 33 age-matched French Canadian whites with essential hypertension. Renal blood flow and glomerular filtration rate were measured by using a constant-infusion technique of PAH and inulin, respectively. Studies were conducted on an inpatient clinical research center, and antihypertensive medications had been discontinued for at least 1 week. Based on 24-hour blood pressure monitoring, nighttime blood pressures decreased (P