Superhydrophilic poly(L-lactic acid) electrospun membranes for biomedical applications obtained by argon and oxygen plasma treatment
Superhydrophilic poly(L-lactic acid) electrospun membranes for biomedical applications obtained by argon and oxygen plasma treatment
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DOI：
10.1016/j.apsusc.2016.02.121
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发表时间：
2016-05-15
影响因子：
6.7
通讯作者：
Lanceros-Mendez, S.
中科院分区：
文献类型：
--
作者：
Correia, D. M.;Ribeiro, C.;Lanceros-Mendez, S.
聚（L-乳酸），PLLA，电纺膜和薄膜进行等离子体处理，在不同的时间和功率与氩气（Ar）和氧气（O-2），独立，以修改的PLLA膜的疏水性。对于最大暴露时间（970 s）和功率（100 W），Ar和O-2等离子体处理均促进电纺膜的纤维平均尺寸分别从830 +/- 282 nm增加到866 +/- 361 nm和1179 +/- 397 nm。等离子体处理对PLLA的物理化学特性没有影响，如化学结构、聚合物相或结晶度。在另一方面，增加的膜的粗糙度，得到与氩和氧等离子体处理。表面润湿性的研究表明，在接触角的减少与增加等离子体处理时间为一个给定的功率和增加功率为一个给定的时间在膜和薄膜和超亲水性电纺纤维膜。结果表明，氩和氧等离子体处理可以用来定制亲水性的PLLA膜的生物医学应用。MTT法结果表明，Ar和O2-等离子体处理不影响MC 3 T3-E1前成骨细胞的代谢活性。(C)2016爱思唯尔B. V.保留所有权利。
Poly(L-lactic acid), PLLA, electrospun membranes and films were plasma treated at different times and power with argon (Ar) and oxygen (O-2), independently, in order to modify the hydrophobic nature of the PLLA membranes. Both Ar and O-2 plasma treatments promote an increase in fiber average size of the electrospun membranes from 830 +/- 282 nm to 866 +/- 361 and 1179 +/- 397 nm, respectively, for the maximum exposure time (970s) and power (100W). No influence of plasma treatment was detected in the physical-chemical characteristics of PLLA, such as chemical structure, polymer phase or degree of crystallinity. On the other hand, an increase in the roughness of the films was obtained both with argon and oxygen plasma treatments. Surface wettability studies revealed a decrease in the contact angle with increasing plasma treatment time for a given power and with increasing power for a given time in membranes and films and superhydrophilic electrospun fiber membranes were obtained. Results showed that the argon and oxygen plasma treatments can be used to tailor hydrophilicity of PLLA membranes for biomedical applications. MTT assay results indicated that plasma treatments under Ar and O-2 do not influence the metabolic activity of MC3T3-E1 pre-osteoblast cells. (C) 2016 Elsevier B.V. All rights reserved.