Langerhans cells in SLE skin. A role in lymphocyte migration and activation in situ.
Langerhans cells in SLE skin. A role in lymphocyte migration and activation in situ.
复制标题
SLE 皮肤中的朗格汉斯细胞。
DOI：
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发表时间：
1985
影响因子：
2.1
通讯作者：
Eija Johansson
中科院分区：
文献类型：
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作者：
V. Bergroth;Y. Konttinen;Eija Johansson
通过使用单克隆抗 T6 和抗 Ia 抗体以及亲和素-生物素-过氧化物酶复合物染色来研究 SLE 皮肤和粘膜中的朗格汉斯细胞。朗格汉斯细胞存在于自然 SLE 皮肤损伤的细胞浸润中。在用测试抗原诱导的早期皮肤损伤中，朗格汉斯细胞是主要的炎症细胞，这表明朗格汉斯细胞迁移到炎症部位实际上先于淋巴细胞迁移。这些发现与生理和病理条件下树突状细胞在淋巴细胞循环和抗原呈递中的作用的假设一致。在自然和测试抗原诱导的 SLE 病变中，许多浸润性局部 T 淋巴细胞都是活化的 Ia+ 细胞。这表明系统性红斑狼疮中自然和测试抗原诱导的皮肤损伤均存在主动免疫反应。 SLE 皮损中原位免疫调节 T4/T8 比率较低可能表明 T8+ 细胞对局部炎症发挥免疫抑制控制作用。
Langerhans cells in SLE skin and mucosa were studied by using monoclonal anti-T6 and anti-Ia antibodies and avidin-biotin-peroxidase complex staining. Langerhans cells were present in cell infiltrates of natural SLE skin lesions. In developing early skin lesions induced with test antigen, Langerhans cells were the predominant inflammatory cells, suggesting that migration of Langerhans cells into the inflammatory site in fact precedes lymphocyte migration. These findings agree with the hypothesis of the role of dendritic cells in lymphocyte circulation and antigen presentation under physiological and pathological conditions. Many of the infiltrating local T lymphocytes in both natural and test antigen induced SLE lesions were activated Ia+ cells. This suggests an active immune response in both natural and test antigen induced skin lesions in SLE. The low immunomodulatory T4/T8 ratio in situ in SLE skin lesions might suggest that T8+ cells exert immunosuppressive control on the local inflammation.