The Emerging Value of Circular Noncoding RNA Research in Cancer Diagnosis and Treatment.
The Emerging Value of Circular Noncoding RNA Research in Cancer Diagnosis and Treatment.
复制标题
DOI：
10.1158/0008-5472.can-22-3014
复制
发表时间：
2023-03-15
期刊：
影响因子：
11.2
通讯作者：
中科院分区：
文献类型：
--
作者：
环状RNA（circRNA）是最近描述的一类RNA分子，其作为疾病机制的新组分和作为包括癌症在内的多种疾病的潜在生物标志物而引起了大量关注。CircRNA通常是高度保守的，并表现出发育阶段和疾病特异性表达。几项研究报道了与特定癌症类型和患者预后相关的circRNA表达模式。在这里，我们概述了正在进行的注册临床试验，这些试验研究了circRNA作为癌症生物标志物的价值，并讨论了circRNA在临床癌症护理中的潜力。总之，circRNA作为诊断，预测和预后生物标志物正在积极研究，它们作为治疗干预点的潜力激励了正在进行的转化和临床研究。
Circular RNAs (circRNAs) are a recently described class of RNA molecules that have attracted substantial attention as new components of disease mechanisms and as potential biomarkers in multiple diseases, including cancer. CircRNAs are often highly conserved and exhibit developmental stage- and disease-specific expression. Several studies have reported circRNA expression patterns that are associated with specific cancer types and with patient prognosis. Here, we overview the active registered clinical trials that investigate the value of circRNAs as cancer biomarkers and discuss the potential of circRNAs in clinical cancer care. Taken together, circRNAs are actively being investigated as diagnostic, predictive, and prognostic biomarkers, and their potential to serve as therapeutic intervention points motivates ongoing translational and clinical research.