Intravenous Mesenchymal Stem Cells Prevented Rejection of Allogeneic Corneal Transplants by Aborting the Early Inflammatory Response
Intravenous Mesenchymal Stem Cells Prevented Rejection of Allogeneic Corneal Transplants by Aborting the Early Inflammatory Response
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DOI：
10.1038/mt.2012.165
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发表时间：
2012-11-01
影响因子：
12.4
通讯作者：
Prockop, Darwin J.
中科院分区：
文献类型：
--
作者：
Oh, Joo Youn;Lee, Ryang Hwa;Prockop, Darwin J.
间充质干/祖细胞（MSCs）据报道可提高细胞和器官移植的存活率。然而，其作用方式尚未确定。我们在此利用角膜同种异体移植的小鼠模型，并证明经移植静脉（i.v.）输注人MSCs（hMSCs）可减轻手术早期诱发的炎症，减少角膜和引流淋巴结（DLNs）中抗原呈递细胞（APCs）的活化。随后，免疫排斥反应减少，同种异体移植物的存活时间延长。对人甘油醛 - 3 - 磷酸脱氢酶（GAPDH）的定量检测显示……
Mesenchymal stem/progenitorcells (MSCs)were reported to enhance the survival of cellular and organ transplants. However, their mode of action was not established. We here used a mouse model of corneal allotransplantation and demonstrated that pen-transplant intravenous (i.v.) infusion of human MSCs (hMSCs) decreased the early surgically induced inflammation and reduced the activation of antigen-presenting cells (APCs) in the cornea and draining lymph nodes (DLNs). Subsequently, immune rejection was decreased, and allograft survival was prolonged. Quantitative assays for human GAPDH revealed that