Iodine-123 Metaiodobenzylguanidine Imaging and Carbon-11 Hydroxyephedrine Positron Emission Tomography Compared in Patients With Left Ventricular Dysfunction
Iodine-123 Metaiodobenzylguanidine Imaging and Carbon-11 Hydroxyephedrine Positron Emission Tomography Compared in Patients With Left Ventricular Dysfunction
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DOI：
10.1161/circimaging.109.920538
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发表时间：
2010-09-01
影响因子：
7.5
通讯作者：
Kajinami, Kouji
中科院分区：
文献类型：
--
作者：
Matsunari, Ichiro;Aoki, Hirofumi;Kajinami, Kouji
背景-尽管I-123-间碘苄胍（I-123-MIBG）显像和C-11-羟麻黄碱（C-11-HED）正电子发射断层扫描（PET）都用于评估心脏交感神经支配，但它们之间的关系仍不清楚。目的是确定I-123-MIBG参数（如心脏与纵隔比率（H/M））是否与C-11-HED PET的定量测量相关，并比较I-123-MIBG单光子发射计算机断层扫描（SPECT）和C-11-HED PET之间的图像质量、缺损大小和位置。（平均左心室射血分数，39 +/- 15%）进行I-123-MIBG成像和C-11-HED PET。计算I-123-MIBG的早期（15分钟）、晚期（3小时）H/M和洗脱率（WR）。计算C-11-HED的心肌保留和WR。使用极图方法，缺陷被定义为具有相对活性的区域
Background-Although both I-123-metaiodobenzylguanidine (I-123-MIBG) imaging and C-11-hydroxyephedrine (C-11-HED) positron emission tomography (PET) are used for assessing cardiac sympathetic innervation, their relationship remains unknown. The aims were to determine whether I-123-MIBG parameters such as heart-to-mediastinum ratio (H/M) are associated with quantitative measures by C-11-HED PET and to compare image quality, defect size, and location between I-123-MIBG single-photon emission computed tomography (SPECT) and C-11-HED PET.Methods and Results-Twenty-one patients (mean left ventricular ejection fraction, 39 +/- 15%) underwent I-123-MIBG imaging and C-11-HED PET. Early (15-minute), late (3-hour) H/M, and washout rate (WR) were calculated for I-123-MIBG. Myocardial retention and WR was calculated for C-11-HED. Using a polar map approach, defect was defined as the area with relative activity