Treatment of varicella-zoster virus infections with adenine arabinoside.
Treatment of varicella-zoster virus infections with adenine arabinoside.
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用腺嘌呤阿糖苷治疗水痘带状疱疹病毒感染。
DOI：
10.1093/infdis/131.3.225
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
Diana Mikulec
中科院分区：
文献类型：
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作者：
M. Johnson;James P. Luby;R. Buchanan;Diana Mikulec
本文报告用阿糖腺苷治疗复杂性水痘带状疱疹病毒感染23例。在14例带状疱疹患者中，13例恶性肿瘤患者接受了放射治疗和细胞毒性药物或类固醇治疗。虽然这些患者在治疗前2 - 14天内形成活跃的囊泡，但在用阿糖腺苷治疗的第4天后没有出现新的病变。治疗第三天，1例患者出现带状疱疹性脑炎，3例患者出现严重带状疱疹后神经痛。在9例接受治疗的原发性水痘患者中，6例好转，其中5例有水痘肺炎的证据。三名死亡的水痘患者中有两名免疫抑制，患有进行性病毒性肺炎，水泡液中的病毒滴度持续高;第三名患者是一名患有雷氏综合征的儿童。双盲对照研究将是必要的，以证明阿糖腺苷在治疗水痘带状疱疹病毒感染的疗效。
Twenty-three patients with complicated varicella-zoster virus infections were treated with adenine arabinoside. Of 14 patients with herpes zoster, 13 had malignancy treated with irradiation and cytotoxic agents or steroids. Although the duration of active vesicle formation in these patients ranged from two to 14 days before therapy, no new lesions appeared after the fourth day of treatment with adenine arabinoside. Zoster encephalitis developed in one patient on the third day of treatment, and severe postherpetic neuralgia was seen in three patients. Of nine treated patients with primary varicella, six improved, including five with evidence of varicella pneumonia. Two of the three patients with varicella who died were immunosuppressed and had progressive viral pneumonia with persistently high titers of virus in vesicular fluid; the third pateint was a child with Reye's syndrome. Double-blind controlled studies will be necessary to demonstrate the efficacy of adenine arabinoside in the treatment of infections with varicella-zoster virus.