Thyroid cartilage invasion in laryngeal and hypopharyngeal squamous cell carcinoma treated with total laryngectomy
Thyroid cartilage invasion in laryngeal and hypopharyngeal squamous cell carcinoma treated with total laryngectomy
复制标题
全喉切除术治疗喉及下咽鳞状细胞癌甲状腺软骨侵犯
DOI：
10.1007/s00405-016-4120-4
复制
发表时间：
2016
影响因子：
2.6
通讯作者：
M. Stenner
中科院分区：
文献类型：
--
作者：
M. Koopmann;D. Weiss;M. Steiger;S. Elges;C. Rudack;M. Stenner
本研究的目的是分析计算机断层扫描在检测恶性甲状软骨侵犯方面的准确性。在一项回顾性图表审查中，120 名喉癌和下咽癌患者在全喉切除术前接受了计算机断层扫描。将这些数据与组织学标本进行比较。多排计算机断层扫描 (MDCT) 扫描的阳性预测值 (PPV) 为 76%，阴性预测值 (NPV) 为 69%。 MDCT 的特异性为 89%，敏感性为 46%。放射学疑似软骨侵犯与组织学结果之间的比较显示出显着相关性 (p<0.02)。我们发现软骨侵袭对生存率没有显着影响（5 年总生存率 p= 0.683；5 年无病生存率 p= 0.711）。术前CT扫描是检测软骨肿瘤侵犯的重要手段。
The objective of this study is to analyze the accuracy of computed tomography in detecting malignant thyroid cartilage invasion. In a retrospective chart review, 120 patients with carcinoma of the larynx and hypopharynx underwent computed tomography before total laryngectomy. These data were compared with the histological specimens. Multidetector computed tomography (MDCT) scan had a positive predictive value (PPV) of 76 % and a negative predictive value (NPV) of 69 %. The specificity of MDCT was 89 % and sensitivity was 46 %. Comparison between radiologic suspected cartilage invasion and histologic results showed a significant correlation (p< 0.02). We found no significant impact of cartilage invasion concerning survival rates (5-year overall survivalp= 0.683; 5-year disease-free survivalp= 0.711). Preoperative CT scan is an important instrument in detecting neoplastic cartilage invasion.