MHC class II B genes in the channel catfish (Ictalurus punctatus)
MHC class II B genes in the channel catfish (Ictalurus punctatus)
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DOI：
10.1016/s0145-305x(97)00003-7
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发表时间：
1997-01-01
影响因子：
2.9
通讯作者：
McConnell, TJ
中科院分区：
文献类型：
--
作者：
Godwin, UB;Antao, A;McConnell, TJ
两个不同的cDNA序列的主要组织相容性复合体（MHC）II类β链的斑点叉尾鱼（Ictalurus punctatus）已被确定。这些序列与先前在其他硬骨鱼中鉴定为MHC II类B基因的序列之间的同源性表明它们代表DAB基因座的等位基因。推断的氨基酸序列显示出具有肽结合区的功能多肽链的强有力证据。Southern杂交分析显示癍点叉尾鮰MHC II类B基因的多态性，并建议存在2至4个基因。(C)1997年爱思唯尔科学有限公司
Two different cDNA sequences for major histocompatibility complex (MHC) class II beta chains from the channel catfish (Ictalurus punctatus) have been identified. Homology between these sequences and those previously identified as MHC class II B genes in other teleosts suggests they represent alleles of the DAB locus. The inferred amino acid sequences show strong evidence for a functional polypeptide chain with a peptide binding region. Southern blot analysis reveals polymorphism in the MHC class II B gene(s) of the channel catfish and suggests the presence of two to four genes. (C) 1997 Elsevier Science Ltd.