Extravasation of leukocytes in comparison to tumor cells.
Extravasation of leukocytes in comparison to tumor cells.
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DOI：
10.1186/1478-811x-6-10
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发表时间：
2008-12-04
期刊：
影响因子：
--
通讯作者：
Entschladen, Frank
中科院分区：
文献类型：
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作者：
Strell, Carina;Entschladen, Frank
细胞从血流通过血管内皮迁移到组织中的多步骤过程被称为外渗。白细胞的外渗在分子水平上有相当好的特征，并已在几个方面进行了综述。相对而言，对肿瘤细胞的外渗知之甚少，这是造血转移形成的一部分。虽然白细胞和肿瘤细胞的过程步骤基本相同，即滚动，粘附，迁移（渗出），但涉及的分子不同。另一个重要的区别是白细胞与内皮的相互作用仅暂时改变内皮的完整性，而肿瘤细胞的相互作用导致内皮结构的不可逆损伤。此外，肿瘤细胞利用白细胞作为内皮细胞的连接体用于其外渗。因此，转移的形成间接地易受定位信号的影响，所述定位信号实际上对免疫系统是特异性的。我们在此比较了白细胞和肿瘤细胞的外渗，涉及的受体和定位信号，直接细胞的某些器官和身体的网站。
The multi-step process of the emigration of cells from the blood stream through the vascular endothelium into the tissue has been termed extravasation. The extravasation of leukocytes is fairly well characterized down to the molecular level, and has been reviewed in several aspects. Comparatively little is known about the extravasation of tumor cells, which is part of the hematogenic metastasis formation. Although the steps of the process are basically the same in leukocytes and tumor cells, i.e. rolling, adhesion, transmigration (diapedesis), the molecules that are involved are different. A further important difference is that leukocyte interaction with the endothelium changes the endothelial integrity only temporarily, whereas tumor cell interaction leads to an irreversible damage of the endothelial architecture. Moreover, tumor cells utilize leukocytes for their extravasation as linkers to the endothelium. Thus, metastasis formation is indirectly susceptible to localization signals that are literally specific for the immune system. We herein compare the extravasation of leukocytes and tumor cells with regard to the involved receptors and the localization signals that direct the cells to certain organs and sites of the body.