Angucyclines from an insect-derived actinobacterium Amycolatopsis sp HCa1 and their cytotoxic activity
Angucyclines from an insect-derived actinobacterium Amycolatopsis sp HCa1 and their cytotoxic activity
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来自昆虫来源的放线菌 Amycolatopsis sp HCa1 的安古环素及其细胞毒活性
DOI：
10.1016/j.bmcl.2012.10.048
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发表时间：
2012-12-15
影响因子：
2.7
通讯作者：
Ge, Hui Ming
中科院分区：
文献类型：
--
作者：
Guo, Zhi Kai;Liu, Shou Bai;Ge, Hui Ming
从一株无淀粉放线杆菌中分离得到一种新的血管环素衍生物--阿霉素A(1)和一种新的血管环素--阿霉素B(2)以及5个已知化合物(3-7)。与蝗虫有关的HCA1。通过波谱方法，包括广泛的核磁共振波谱，确定了它们的结构。化合物1-7对人胃腺癌细胞系(BGC823)、人肝癌细胞系(HepG2)、人黑色素瘤细胞系(A375)、口腔鳞癌细胞系(KB)和幽灵细胞系(Ghost-R5X4)进行了体外细胞毒实验。细胞存活率测定显示，化合物7在四种细胞株中均有活性，IC50值小于18.0微米，但在KB细胞中，直到100微米时无活性。(C)2012爱思唯尔有限公司。保留所有权利。
One new angucyclinone derivative, amycomycin A (1), and one new angucycline, amycomycin B (2), along with 5 known compounds (3-7), were isolated from an actinobacterium Amycolatopsis sp. HCa1 associated with the grasshopper, Oxya chinensis. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 1-7 were tested in vitro for their cytotoxic effects on five cell lines including human gastric adenocarcinoma cell line (BGC823), human hepatocarcinoma cell line (HepG2), human melanoma cell line (A375), human oral squamous carcinoma cell line (KB), and ghost cell line (Ghost-R5X4). Cell viability assays showed that compound 7 was active in four cell lines with IC50 values less than 18.0 mu M except in KB showing no activity up to 100 mu M. (C) 2012 Elsevier Ltd. All rights reserved.