Molecularly imprinted polymer prepared with polyhedral oligomeric silsesquioxane through reversible addition-fragmentation chain transfer polymerization
Molecularly imprinted polymer prepared with polyhedral oligomeric silsesquioxane through reversible addition-fragmentation chain transfer polymerization
复制标题
多面体低聚倍半硅氧烷可逆加成断裂链转移聚合制备分子印迹聚合物
DOI：
10.1007/s00216-017-0315-9
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发表时间：
2017
影响因子：
4.3
通讯作者：
Liu Zhao-Sheng
中科院分区：
文献类型：
--
作者：
Gao Shu-Ping;Zhang Xue;Zhang Li-Shun;Huang Yan-Ping;Liu Zhao-Sheng
利用多面体低聚倍半硅氧烷（POSS）通过可逆加成-断裂链转移聚合（RAFT）成功制备了分子印迹聚合物。以酮洛芬（KET）为模板分子，以RAFT试剂4-乙烯基吡啶（4-VP）、POSS单体[PSS-（1-甲基丙烯酸丙酯）-七异丁基取代的，MA 0702]和乙二醇二甲基丙烯酸酯（EDMA）为单体，制备了分子印迹聚合物。考察了聚合反应条件、RAFT试剂用量、POSS单体用量、KET与4-VP的比例、4-VP与EDMA的比例对印迹效果和保留因子的影响。基于RAFT试剂的POSS分子印迹聚合物的最大印迹因子为15.2，约为无RAFT试剂的POSS分子印迹聚合物的1.5倍。研究了含RAFT剂和不含RAFT剂的POSS MIP整体材料的渗透率、表面形貌和孔径分布。将优化的MIP用于KET的固相萃取。RAFT-POSS MIP的平均回收率为85.2%，相对标准偏差为2.6%。
Polyhedral oligomeric silsesquioxane (POSS) was utilized to prepare imprinted polymer through reversible addition–fragmentation chain transfer polymerization (RAFT) successfully. The imprinted polymer was made with a mixture of RAFT agent, 4-vinylpyridine (4-VP), POSS monomer [PSS-(1-propylmethacrylate)-heptaisobutyl substituted, MA 0702], and ethylene glycol dimethacrylate (EDMA), with ketoprofen (KET) as template. The influence of polymerization variables, the amount of RAFT agent and POSS monomer, the ratio of KET to 4-VP, and the ratio of 4-VP to EDMA, were investigated on the retention factor and imprinting effect. The greatest imprinting factor of the RAFT agent-based POSS MIP was 15.2, about 1.5 times higher than the RAFT agent-free agent POSS MIP. The permeability, surface morphology, as well as pore size distribution of POSS MIP monoliths made with RAFT agent and without RAFT agent were also studied. The optimal MIP was applied to solid phase extraction for KET from commercial tablets. The mean recoveries of KET for RAFT-based POSS MIP was 85.2% with a relative standard deviation of 2.6%.