Biomechanical Testing of a Novel Device for Sutureless Nerve Repair.
Biomechanical Testing of a Novel Device for Sutureless Nerve Repair.
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无缝神经修复新型装置的生物力学测试。
DOI：
10.1089/ten.tec.2022.0080
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Isaacs,JonathanE
中科院分区：
文献类型：
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作者：
Bendale,GeetanjaliS;Sonntag,Maximilian;Clements,IsaacP;Isaacs,JonathanE
用传统神经修复技术获得的次优神经末梢对齐可能会导致较差的临床结果。在这项研究中，我们介绍了一种新型神经修复设备--NuroTape®，它将灵活的镍钛醇微钩柱集成到生物背衬中，以缠绕、对准和固定接近的神经末梢。本研究比较了神经胶带与传统微缝合法的修复强度。对30条小直径(2 mm)和30条大直径(7 mm)的人身体神经进行横断，并采用神经胶带或适当的显微缝合技术进行修复。生物力学测试使用水平拉伸测试仪进行。以40 mm/m in的牵张速率加载修复后的神经直至失效，并确定最大失效载荷。在小神经组中，神经胶带修复组(2.33 ± 0.66 N)显著高于缝合修复组(1.22 ± 0.52 N；p<； 0.05)。在大神经组中，神经胶带修复组(7.45 ± 2.66 N)和缝合修复组(5.82 ± 1.59 N：P= 0.12)之间的负荷-失效差异无统计学意义。缝合修复往往因断裂而失败，而神经胶带失败则是由于微钩拔出造成的。神经胶带是一种新型的神经缝合装置，其机械修复强度与临床相关的显微缝合修复相当或更大。
Suboptimal nerve end alignment achieved with conventional nerve repair techniques may contribute to poor clinical outcomes. In this study, we introduce Nerve Tape®, a novel nerve repair device that integrates flexible columns of Nitinol microhooks within a biologic backing to entubulate, align, and secure approximated nerve ends. This study compares the repair strength of Nerve Tape with that of conventional microsuture repairs. Thirty small (2 mm) and 30 large (7 mm) diameter human cadaveric nerves were transected and repaired utilizing Nerve Tape or appropriate microsuture technique. Biomechanical testing was performed using a horizontal tensile tester. The repaired nerves were loaded until failure at a distraction rate of 40 mm/min, and the maximum failure load was determined. In the small nerve groups, the load-to-failure for Nerve Tape repairs (2.33 ± 0.66 N) was significantly higher than for suture repairs (1.22 ± 0.52 N;p< 0.05). In the large nerve groups, no significant difference in load-to-failure was found between Nerve Tape (7.45 ± 2.66 N) and suture repairs (5.82 ± 1.59 N:p= 0.12). Suture repairs tended to fail by rupture, whereas Nerve Tape failures resulted from microhook pullout. Nerve Tape is a novel nerve coaptation device that provides mechanical repair strength equal or greater to clinically relevant microsuture repairs.