Interplay between FAK, PKCδ, and p190RhoGAP in the regulation of endothelial barrier function.
Interplay between FAK, PKCδ, and p190RhoGAP in the regulation of endothelial barrier function.
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DOI：
10.1016/j.mvr.2011.04.005
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发表时间：
2012-01
影响因子：
3.1
通讯作者：
Harrington EO
中科院分区：
文献类型：
--
作者：
Grinnell KL;Harrington EO
Disruption of either intercellular or extracellular junctions involved in maintaining endothelial barrier function can result in increased endothelial permeability. Increased endothelial permeability, in turn, allows for the unregulated movement of fluid and solutes out of the vasculature and into the surrounding connective tissue, contributing to a number of disease states, including stroke and pulmonary edema. Thus, a better understanding of the molecular mechanisms by which endothelial cell junction integrity is controlled is necessary for development of therapies aimed at treating such conditions. In this review, we will discuss the functions of three signaling molecules known to be involved in regulation of endothelial permeability: focal adhesion kinase (FAK), protein kinase C delta (PKCδ), and p190RhoGAP (p190). We will discuss the independent functions of each protein, as well as the interplay that exists between them and the effects of such interactions on endothelial function.
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DOI：
10.1152/ajplung.00174.2001
发表时间：
2002-05-01
影响因子：
4.9
作者：
Bellas, RE;Harrington, EO;Rounds, S
通讯作者：
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DOI：
10.1073/pnas.95.10.5579
发表时间：
1998-05-12
影响因子：
11.1
作者：
Claesson-Welsh, L;Welsh, M;Folkman, J
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Burridge, K
影响因子：
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作者：
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Reyland, ME
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作者：
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van Hinsbergh, VWM