Metabolic factors in diffuse idiopathic skeletal hyperostosis - a review of clinical data.
Metabolic factors in diffuse idiopathic skeletal hyperostosis - a review of clinical data.
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DOI：
10.2174/1874312901408010116
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Littlejohn G
中科院分区：
文献类型：
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作者：
Pillai S;Littlejohn G
我们的目的是回顾有关代谢因子与弥漫性特发性骨骼肥厚症（DISH）的文献，以评估生长因子与DISH之间的关系。我们在我们的个人数据库和PubMed中以不同的组合使用以下关键词识别研究：“弥漫性特发性骨骼增生”、“强直性骨质增生”、“弗雷斯捷病”、“糖尿病”、“胰岛素”、“肥胖”、“代谢”、“生长因子”、“脂肪因子”、“葡萄糖耐量”和“软骨细胞”。由于研究方法的可变性，我们无法进行系统评价。我们发现肥胖（尤其是腹部肥胖）、2型糖尿病、葡萄糖不耐受、高胰岛素血症和DISH之间存在正相关。目前的研究表明，某些代谢因素与DISH有关。需要从这些发现和其他新发现的骨骼生长因子中得出更精确的研究。
We aimed to review the literature linking metabolic factors to Diffuse Idiopathic Skeletal Hyperostosis (DISH), in order to assess associations between growth factors and DISH. We identified studies in our personal database and PubMed using the following keywords in various combinations: “diffuse idiopathic skeletal hyperostosis”, “ankylosing hyperostosis”, “Forestier’s disease”, “diabetes”, “insulin”, “obesity”, “metabolic”, “growth factors”, “adipokines”, “glucose tolerance” and “chondrocytes”. We were not able to do a systematic review due to variability in methodology of studies. We found positive associations between obesity (especially abdominal obesity), Type 2 diabetes mellitus, glucose intolerance, hyperinsulinemia and DISH. Current research indicates that certain metabolic factors associate with DISH. More precise studies deriving from these findings on these and other newly identified bone-growth factors are needed.